☆ 4.6 Article

Perspective: mitochondrial STAT3 in cardioprotection

BASIC RESEARCH IN CARDIOLOGY (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Cardiac & Cardiovascular Systems

No sex-related differences in infarct size, no-reflow, and protection by ischaemic pre-conditioning in Gottingen minipigs

Petra Kleinbongard et al.

Summary: This study compared the infarct size in female, castrated male, and male pigs undergoing ischemia/reperfusion (I/R) and ischemic preconditioning (IPC). The results showed no sex- or castration-related differences in infarct size, coronary microvascular injury, and cardioprotection by IPC.

CARDIOVASCULAR RESEARCH (2023)

添加到收藏夹

Review Pharmacology & Pharmacy

Interaction of Cardiovascular Nonmodifiable Risk Factors, Comorbidities and Comedications With Ischemia/Reperfusion Injury and Cardioprotection by Pharmacological Treatments and Ischemic Conditioning

Peter Ferdinandy et al.

Summary: Preconditioning, postconditioning, and remote conditioning of the myocardium have the potential to provide novel therapeutic paradigms for cardioprotection. However, the lack of rigorous preclinical evaluation and consideration of cardiovascular risk factors and comorbidities may be a major reason for the failure to develop cardioprotective drugs.

PHARMACOLOGICAL REVIEWS (2023)

添加到收藏夹

Article Anesthesiology

Dexmedetomidine Pretreatment Protects Against Myocardial Ischemia/Reperfusion Injury by Activating STAT3 Signaling

Zhao-Rong Chen et al.

Summary: This study found that Dexmedetomidine (DEX) pretreatment can protect against myocardial ischemia/reperfusion injury (IRI) by promoting STAT3 phosphorylation. In both in vivo and in vitro experiments, DEX pretreatment reduced serum creatine kinase-MB isoenzyme (CK-MB) levels, suppressed inflammatory response, decreased cell apoptosis, and promoted STAT3 phosphorylation. These effects are believed to be mediated through the α2-adrenoreceptor and STAT3 signaling pathway.

ANESTHESIA AND ANALGESIA (2023)

添加到收藏夹

Editorial Material Cardiac & Cardiovascular Systems

A primordial obstacle in cardioprotection: the answer resides in our genes

Gemma Vilahur

CARDIOVASCULAR RESEARCH (2023)

添加到收藏夹

Editorial Material Cardiac & Cardiovascular Systems

Primordial non-responsiveness: a neglected obstacle to cardioprotection

Gerd Heusch et al.

EUROPEAN HEART JOURNAL (2023)

添加到收藏夹

Review Immunology

Advances in the role of STAT3 in macrophage polarization

Tingting Xia et al.

Summary: Cell growth, proliferation, differentiation, and apoptosis are influenced by STAT3, and aberrant STAT3 expression affects the development of inflammatory immunological disorders, fibrotic diseases, and malignancies. Macrophages (M0) can be polarized into pro-inflammatory (M1) and anti-inflammatory (M2) types, and STAT3 signaling plays a role in this polarization. This review compiles the relevant signaling pathways associated with STAT3 and macrophage polarization for the treatment and investigation of disorders related to macrophage polarization.

FRONTIERS IN IMMUNOLOGY (2023)

添加到收藏夹

Letter Cardiac & Cardiovascular Systems

Sodium Glucose Cotransporter-2 Inhibitor Empagliflozin Reduces Infarct Size Independently of Sodium Glucose Cotransporter-2

Sha Chen et al.

CIRCULATION (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

Mitochondrial dysfunction and cardiac ischemia/reperfusion injury are attenuated by nandrolone: Role of JAK-STAT3 pathway

Aina E. Domingos et al.

Summary: The aim of this study was to investigate the effect of acute treatment with nandrolone decanoate on cardiac ischemia/reperfusion injury. The results suggest that nandrolone decanoate can provide cardioprotection through recruiting the JAK-STAT3 signaling pathway and preserving mitochondria.

STEROIDS (2023)

添加到收藏夹

Editorial Material Cardiac & Cardiovascular Systems

Cardioprotection in cardio-oncology: a case for concern?

Gerd Heusch

CARDIOVASCULAR RESEARCH (2023)

添加到收藏夹

Letter Cardiac & Cardiovascular Systems

Sodium Glucose Cotransporter-2 Inhibitor Empagliflozin Reduces Infarct Size Independently of Sodium Glucose Cotransporter-2

Sha Chen et al.

CIRCULATION (2023)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

The heterocellular heart: identities, interactions, and implications for cardiology

Achim Lother et al.

Summary: The heterocellular nature of the heart, including non-myocytes cells, has gained increasing attention in recent years. Single-cell sequencing technologies have enabled the identification of subtle differences and prompted a reexamination of cell identity. This article provides an overview of major cardiac cell types, their roles in homeostasis, and recent findings on non-canonical functions that may be relevant for cardiology.

BASIC RESEARCH IN CARDIOLOGY (2023)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Cardioprotection and its Translation: A Need for New Paradigms? Or for New Pragmatism? An Opinionated Retro- and Perspective

Gerd Heusch

Summary: The dawn of cardioprotection focused on altering the oxygen demand-supply balance of the ischemic/infarcting myocardium, but this idea may not be correct since the myocardium does not contract during ischemia/infarction. Timely reperfusion is the only successful clinical practice for reducing infarct size. Although there have been positive preclinical studies on cardioprotection mechanisms, they have not translated into clinical practice. Researchers are currently exploring the obstacles and waiting for innovative breakthroughs.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS (2023)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

The RISK pathway leading to mitochondria and cardioprotection: how everything started

Derek M. Yellon et al.

Summary: Ischaemic heart disease is a leading cause of death worldwide, and despite the development of several cardioprotective therapies, clinical translation has been disappointing. However, targeting the 'reperfusion injury salvage kinase' (RISK) pathway shows promise for cardioprotection. This pathway plays a crucial role in preventing mitochondrial permeability transition pore (MPTP) opening and cardiac cell death.

BASIC RESEARCH IN CARDIOLOGY (2023)

添加到收藏夹

Review Biochemistry & Molecular Biology

Importance of Mitochondria in Cardiac Pathologies: Focus on Uncoupling Proteins and Monoamine Oxidases

Rainer Schulz et al.

Summary: Reactive oxygen species (ROS) play dual roles in disease development and cell signaling pathways. Cardiomyocytes generate the largest amount of ROS through mitochondria. Uncoupling protein (UCP) and monoamine oxidases (MAO) have been identified as modifiers of mitochondrial ROS formation. This review highlights the role of UCP and MAO in cardiac injuries induced by ischemia-reperfusion (I/R) and their potential for protection from I/R and heart failure.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

添加到收藏夹

Article Multidisciplinary Sciences

Differential remodelling of mitochondrial subpopulations and mitochondrial dysfunction are a feature of early stage diabetes

Bodour S. Rajab et al.

Summary: Research reveals that mitochondrial morphology, dynamics and function are dysregulated in the early stages of diabetes, characterized by enlarged mitochondria, irregular shape, increased tubular projections, increased density, decreased complex activity and increased oxygen consumption rate.

SCIENTIFIC REPORTS (2022)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Cardioprotection by selective SGLT-2 inhibitors in a non-diabetic mouse model of myocardial ischemia/reperfusion injury: a class or a drug effect?

Panagiota Efstathia Nikolaou et al.

Summary: This study compared three selective SGLT-2 inhibitors in terms of their effects on ischemia reperfusion injury and revealed their mechanism of cardioprotection in healthy non-diabetic mice. The results showed that EMPA and DAPA, but not ERTU, at the stoichiometrically equivalent dose (SED) reduced infarct size (IS) and were associated with the activation of NF-kB, RISK, and STAT-3, as well as increased expression of FGF-2 and Cav-3.

BASIC RESEARCH IN CARDIOLOGY (2022)

添加到收藏夹

Article Cell Biology

Differential Effects of Reperfusion on Cardiac Mitochondrial Subpopulations in a Preclinical Porcine Model of Acute Myocardial Infarction

Kadambari Chandra Shekar et al.

Summary: In a pre-clinical porcine model of acute myocardial infarction (AMI), there were no consistent individual functional differences observed between subsarcolemmal and interfibrillar mitochondria during the initial few hours of reperfusion.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Cellular Heterogeneity of the Heart

Nathaly Anto Michel et al.

Summary: Recent technological advancements have allowed scientists to gain a more detailed understanding of the cellular composition of the human heart, which is crucial for studying cardiac physiology and pathological transformation.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2022)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Empagliflozin in acute myocardial infarction: the EMMY trial

Dirk von Lewinski et al.

Summary: This study investigated the effects of empagliflozin on patients following acute myocardial infarction, showing significant reductions in NT-proBNP and improvements in echocardiographic parameters.

EUROPEAN HEART JOURNAL (2022)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Remote ischemic conditioning in Ossabaw minipigs induces the release of humoral cardioprotective triggers, but the myocardium does not respond with reduced infarct size

Helmut Raphael Lieder et al.

Summary: Ischemic preconditioning (IPC) reduces infarct size through trigger molecule release and activation of STAT3. However, IPC failed to protect Ossabaw minipigs from infarction, while remote ischemic conditioning (RIC) induced the release of cardioprotective triggers and reduced infarct size.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2022)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Non-responsiveness to cardioprotection by ischaemic preconditioning in Ossabaw minipigs with genetic predisposition to, but without the phenotype of the metabolic syndrome

Petra Kleinbongard et al.

Summary: The study found that Ossabaw minipigs, despite having a genetic predisposition to develop a metabolic syndrome, were not responsive to cardioprotective interventions such as ischemic preconditioning.

BASIC RESEARCH IN CARDIOLOGY (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Chronic Empagliflozin Treatment Reduces Myocardial Infarct Size in Nondiabetic Mice Through STAT-3-Mediated Protection on Microvascular Endothelial Cells and Reduction of Oxidative Stress

Panagiota Efstathia Nikolaou et al.

Summary: Chronic administration of empagliflozin reduces infarct size in healthy mice through the STAT-3 pathway and increases the survival of endothelial cells, independently of diabetes mellitus.

ANTIOXIDANTS & REDOX SIGNALING (2021)

添加到收藏夹

Editorial Material Cardiac & Cardiovascular Systems

Protection from cardiotoxicity of cancer chemotherapy: a novel target for remote ischaemic conditioning?

Gerd Heusch et al.

CARDIOVASCULAR RESEARCH (2021)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Regulation of STAT3 and its role in cardioprotection by conditioning: focus on non-genomic roles targeting mitochondrial function

Stefano Comita et al.

Summary: Cardioprotective conditioning strategies such as pre- and post-conditioning maneuvers play a crucial role in stimulating pro-survival pathways like STAT3 for the preservation of cardiac health. The importance of STAT3 as a promoter of metabolic network and its interactions with processes aimed at maintaining mitochondrial functions have been highlighted in understanding cardioprotection phenomena.

BASIC RESEARCH IN CARDIOLOGY (2021)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Mitochondrial Telomerase Reverse Transcriptase Protects From Myocardial Ischemia/Reperfusion Injury by Improving Complex I Composition and Function

Niloofar Ale-Agha et al.

Summary: By generating new mouse models with either mitochondrial TERT or nuclear TERT, it was discovered that mitochondrial TERT plays a critical role in protecting the heart, improving complex I activity, reducing infarct size, and promoting vascularization. Mitochondrial TERT has positive effects on the functions of cardiomyocytes, fibroblasts, and endothelial cells, suggesting therapeutic potential for cardiac protection.

CIRCULATION (2021)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Mitochondrial contributions to vascular endothelial dysfunction, arterial stiffness, and cardiovascular diseases

Danielle L. Kirkman et al.

Summary: Cardiovascular disease is a leading cause of death in America, with advancing age being a major risk factor. Vascular dysfunction, characterized by endothelial dysfunction and large elastic artery stiffening, is associated with an increased CVD risk. Mitochondria play a crucial role in maintaining vascular homeostasis, and age- and disease-related impairments in mitochondrial function contribute to vascular dysfunction and increase CVD risk.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2021)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT) criteria: guidelines of the EU-CARDIOPROTECTION COST Action

Sandrine Lecour et al.

Summary: The researchers proposed a set of standards called IMPACT to improve the evaluation of cardioprotective interventions before entering clinical studies, aiming to increase the likelihood of translating novel cardioprotective interventions into beneficial clinical practice for patients.

BASIC RESEARCH IN CARDIOLOGY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

The genome of the naturally evolved obesity-prone Ossabaw miniature pig

Yaolei Zhang et al.

Summary: The feral pigs on Ossabaw Island have a strong tendency towards obesity and can develop metabolic syndrome on a high energy diet. The high-quality genome of the Ossabaw pig revealed unique genomic variations that may be related to its thrifty phenotype, including a significant inversion. Additionally, a positively selected gene, leptin receptor, was identified as potentially playing a key role in obesity and inflammation development.

ISCIENCE (2021)

添加到收藏夹

Review Pharmacology & Pharmacy

Co-morbidities and co-medications as confounders of cardioprotection-Does it matter in the clinical setting?

Petra Kleinbongard et al.

BRITISH JOURNAL OF PHARMACOLOGY (2020)

添加到收藏夹

Review Engineering, Biomedical

Swine Disease Models for Optimal Vascular Engineering

Michael Sturek et al.

ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 22 (2020)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Transcriptional and Cellular Diversity of the Human Heart

Nathan R. Tucker et al.

CIRCULATION (2020)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Remote ischemic preconditioning reduces myocardial ischemia-reperfusion injury through unacylated ghrelin-induced activation of the JAK/STAT pathway

Yasuaki Sawashita et al.

BASIC RESEARCH IN CARDIOLOGY (2020)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Myocardial ischaemia-reperfusion injury and cardioprotection in perspective

Gerd Heusch

NATURE REVIEWS CARDIOLOGY (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Cells of the adult human heart

Monika Litvinukova et al.

NATURE (2020)

添加到收藏夹

Editorial Material Pharmacology & Pharmacy

Risk factors, co-morbidities, and co-medications in cardioprotection: Importance for translation

Rainer Schulz et al.

BRITISH JOURNAL OF PHARMACOLOGY (2020)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Targeting mitochondria for cardiovascular disorders: therapeutic potential and obstacles

Massimo Bonora et al.

NATURE REVIEWS CARDIOLOGY (2019)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Critical appraisal of STAT3 pattern in adult cardiomyocytes

Zeina Harhous et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2019)

添加到收藏夹

Editorial Material Cell Biology

The anti-inflammatory effects of SGLT inhibitors

Alvaro Garcia-Ropero et al.

AGING-US (2019)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Cardioprotection of post-ischemic moderate ROS against ischemia/reperfusion via STAT3-induced the inhibition of MCU opening

Lan Wu et al.

BASIC RESEARCH IN CARDIOLOGY (2019)

添加到收藏夹

Article Medicine, General & Internal

Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2/ERIC-PPCI): a single-blind randomised controlled trial

Derek J. Hausenloy et al.

LANCET (2019)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

The coronary circulation in acute myocardial ischaemia/reperfusion injury: a target for cardioprotection

Derek J. Hausenloy et al.

CARDIOVASCULAR RESEARCH (2019)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Egr-1 functions as a master switch regulator of remote ischemic preconditioning-induced cardioprotection

M. Billah et al.

BASIC RESEARCH IN CARDIOLOGY (2019)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

An Update on the Multifaceted Roles of STAT3 in the Heart

Zeina Harhous et al.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2019)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Humoral transfer and intramyocardial signal transduction of protection by remote ischemic perconditioning in pigs, rats, and mice

Andreas Skyschally et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2018)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Mitochondria THE target of myocardial conditioning

Kerstin Boengler et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2018)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Randomized controlled trial of remote ischaemic conditioning in ST-elevation myocardial infarction as adjuvant to primary angioplasty (RIC-STEMI)

Antonio Gaspar et al.

BASIC RESEARCH IN CARDIOLOGY (2018)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Stat5-dependent cardioprotection in late remote ischaemia preconditioning

Hui Chen et al.

CARDIOVASCULAR RESEARCH (2018)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Reflection of Cardioprotection by Remote Ischemic Perconditioning in Attenuated ST-Segment Elevation During Ongoing Coronary Occlusion in Pigs Evidence for Cardioprotection From Ischemic Injury

Petra Kleinbongard et al.

CIRCULATION RESEARCH (2018)

添加到收藏夹

Editorial Material Cardiac & Cardiovascular Systems

Cardioprotection research must leave its comfort zone

Gerd Heusch

EUROPEAN HEART JOURNAL (2018)

添加到收藏夹

Letter Cardiac & Cardiovascular Systems

Persistent Survival Benefit From Remote Ischemic Pre-Conditioning in Patients Undergoing Coronary Artery Bypass Surgery

Petra Kleinbongard et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2018)

添加到收藏夹

Article Pharmacology & Pharmacy

Nagarse treatment of cardiac subsarcolemmal and interfibrillar mitochondria leads to artefacts in mitochondrial protein quantification

Gabor Koncsos et al.

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2018)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Mitochondrial and Contractile Function of Human Right Atrial Tissue in Response to Remote Ischemic Conditioning

Petra Kleinbongard et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2018)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Vago-Splenic Axis in Signal Transduction of Remote Ischemic Preconditioning in Pigs and Rats

Helmut Raphael Lieder et al.

CIRCULATION RESEARCH (2018)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

STAT3 as a common signal of ischemic conditioning: a lesson on rigor and reproducibility in preclinical studies on cardioprotection

Petra Kleinbongard et al.

BASIC RESEARCH IN CARDIOLOGY (2018)

添加到收藏夹

Review Physiology

Cardioprotection by remote ischemic conditioning and its signal transduction

Petra Kleinbongard et al.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2017)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Ischemic preconditioning in pigs: a causal role for signal transducer and activator of transcription 3

Sabine Gent et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2017)

添加到收藏夹

Editorial Material Cardiac & Cardiovascular Systems

ERICCA and RIPHeart: two nails in the coffin for cardioprotection by remote ischemic conditioning? Probably not!

Gerd Heusch et al.

EUROPEAN HEART JOURNAL (2016)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Understanding STAT3 signaling in cardiac ischemia

K. E. O'Sullivan et al.

BASIC RESEARCH IN CARDIOLOGY (2016)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Time to Give Up on Cardioprotection?: A Critical Appraisal of Clinical Studies on Ischemic Pre-, Post-, and Remote Conditioning*

Gerd Heusch et al.

CIRCULATION RESEARCH (2016)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Mitochondrial Function, Biology, and Role in Disease A Scientific Statement From the American Heart Association

Elizabeth Murphy et al.

CIRCULATION RESEARCH (2016)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Cardioprotective function of mitochondrial-targeted and transcriptionally inactive STAT3 against ischemia and reperfusion injury

Karol Szczepanek et al.

BASIC RESEARCH IN CARDIOLOGY (2015)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Molecular Basis of Cardioprotection Signal Transduction in Ischemic Pre-, Post-, and Remote Conditioning

Gerd Heusch

CIRCULATION RESEARCH (2015)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Across-Species Transfer of Protection by Remote Ischemic Preconditioning With Species-Specific Myocardial Signal Transduction by Reperfusion Injury Salvage Kinase and Survival Activating Factor Enhancement Pathways

Andreas Skyschally et al.

CIRCULATION RESEARCH (2015)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Cardioprotection by combined intrahospital remote ischaemic perconditioning and postconditioning in ST-elevation myocardial infarction: the randomized LIPSIA CONDITIONING trial

Ingo Eitel et al.

EUROPEAN HEART JOURNAL (2015)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Remote Ischemic Conditioning Reduces Myocardial Infarct Size and Edema in Patients With ST-Segment Elevation Myocardial Infarction

Steven K. White et al.

JACC-CARDIOVASCULAR INTERVENTIONS (2015)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

ROS generated during early reperfusion contribute to intermittent hypobaric hypoxia-afforded cardioprotection against postischemia-induced Ca2+ overload and contractile dysfunction via the JAK2/STAT3 pathway

Lan Wu et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2015)

添加到收藏夹

Letter Cardiac & Cardiovascular Systems

Remote Ischemic Conditioning Reduces Myocardial Infarct Size in STEMI Patients Treated by Thrombolysis

Derek M. Yellon et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2015)

添加到收藏夹

Article Medicine, General & Internal

Remote Ischemic Preconditioning and Outcomes of Cardiac Surgery

D. J. Hausenloy et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

添加到收藏夹

Article Medicine, General & Internal

A Multicenter Trial of Remote Ischemic Preconditioning for Heart Surgery

P. Meybohm et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Effect of remote ischaemic preconditioning on clinical outcomes in patients undergoing cardiac bypass surgery: a randomised controlled clinical trial

Luciano Candilio et al.

HEART (2015)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

STAT3, a key regulator of cell-to-cell communication in the heart

Arash Haghikia et al.

CARDIOVASCULAR RESEARCH (2014)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Improved long-term clinical outcomes in patients with ST-elevation myocardial infarction undergoing remote ischaemic conditioning as an adjunct to primary percutaneous coronary intervention

Astrid D. Sloth et al.

EUROPEAN HEART JOURNAL (2014)

添加到收藏夹

Review Immunology

Toward a new STATe: The role of STATs in mitochondrial function

Jeremy A. Meier et al.

SEMINARS IN IMMUNOLOGY (2014)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Diazoxide postconditioning induces mitochondrial protein S-Nitrosylation and a redox-sensitive mitochondrial phosphorylation/translocation of RISK elements: no role for SAFE

C. Penna et al.

BASIC RESEARCH IN CARDIOLOGY (2013)

添加到收藏夹

Article Pharmacology & Pharmacy

The STAT3 Inhibitor Stattic Impairs Cardiomyocyte Mitochondrial Function Through Increased Reactive Oxygen Species Formation

Kerstin Boengler et al.

CURRENT PHARMACEUTICAL DESIGN (2013)

添加到收藏夹

Article Biochemistry & Molecular Biology

The Import of the Transcription Factor STAT3 into Mitochondria Depends on GRIM-19, a Component of the Electron Transport Chain

Prasad Tammineni et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

添加到收藏夹

Article Medicine, General & Internal

Cardioprotective and prognostic effects of remote ischaemic preconditioning in patients undergoing coronary artery bypass surgery: a single-centre randomised, double-blind, controlled trial

Matthias Thielmann et al.

LANCET (2013)

添加到收藏夹

Review Medicine, General & Internal

Cardioprotection: chances and challenges of its translation to the clinic

Gerd Heusch

LANCET (2013)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Remote ischaemic preconditioning down-regulates kinin receptor expression in neutrophils of patients undergoing heart surgery

Pankaj Saxena et al.

INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY (2013)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Effects of Remote Ischemic Preconditioning With Postconditioning in Patients Undergoing Off-Pump Coronary Artery Bypass Surgery - Randomized Controlled Trial -

Deok Man Hong et al.

CIRCULATION JOURNAL (2012)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

STAT5 Activation and Cardioprotection by Remote Ischemic Preconditioning in Humans

Gerd Heusch et al.

CIRCULATION RESEARCH (2012)

添加到收藏夹

Article Physiology

Dynamic micro- and macrovascular remodeling in coronary circulation of obese Ossabaw pigs with metabolic syndrome

Aaron J. Trask et al.

JOURNAL OF APPLIED PHYSIOLOGY (2012)

添加到收藏夹

Article Multidisciplinary Sciences

Cardiac Subsarcolemmal and Interfibrillar Mitochondria Display Distinct Responsiveness to Protection by Diazoxide

Ekhson L. Holmuhamedov et al.

PLOS ONE (2012)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

STAT subtype specificity and ischemic preconditioning in mice: is STAT-3 enough?

Michael D. Goodman et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2011)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

RISK and SAFE signaling pathway interactions in remote limb ischemic perconditioning in combination with local ischemic postconditioning

Sophie Tamareille et al.

BASIC RESEARCH IN CARDIOLOGY (2011)

添加到收藏夹

Article Hematology

Association of JAK-STAT pathway related genes with lymphoma risk: results of a European case-control study (EpiLymph)

Katja Butterbach et al.

BRITISH JOURNAL OF HAEMATOLOGY (2011)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

H11 Kinase/Heat Shock Protein 22 Deletion Impairs Both Nuclear and Mitochondrial Functions of STAT3 and Accelerates the Transition Into Heart Failure on Cardiac Overload

Hongyu Qiu et al.

CIRCULATION (2011)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Mitochondrial STAT3 Activation and Cardioprotection by Ischemic Postconditioning in Pigs With Regional Myocardial Ischemia/Reperfusion

Gerd Heusch et al.

CIRCULATION RESEARCH (2011)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

STAT3 and cardiac remodeling

Arash Haghikia et al.

HEART FAILURE REVIEWS (2011)

添加到收藏夹

Article Biochemistry & Molecular Biology

Mitochondrial-targeted Signal Transducer and Activator of Transcription 3 (STAT3) Protects against Ischemia-induced Changes in the Electron Transport Chain and the Generation of Reactive Oxygen Species

Karol Szczepanek et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

A murine model of inducible, cardiac-specific deletion of STAT3: Its use to determine the role of STAT3 in the upregulation of cardioprotective proteins by ischemic preconditioning

Roberto Bolli et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2011)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

The in-situ pig heart with regional ischemia/reperfusion - Ready for translation

Gerd Heusch et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2011)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Inhibition of permeability transition pore opening by mitochondrial STAT3 and its role in myocardial ischemia/reperfusion

Kerstin Boengler et al.

BASIC RESEARCH IN CARDIOLOGY (2010)

添加到收藏夹

Article Biochemistry & Molecular Biology

Stoichiometry of STAT3 and Mitochondrial Proteins IMPLICATIONS FOR THE REGULATION OF OXIDATIVE PHOSPHORYLATION BY PROTEIN-PROTEIN INTERACTIONS

Darci Phillips et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

添加到收藏夹

Article Medicine, General & Internal

Remote ischaemic conditioning before hospital admission, as a complement to angioplasty, and effect on myocardial salvage in patients with acute myocardial infarction: a randomised trial

Hans Erik Botker et al.

LANCET (2010)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Presence of connexin 43 in subsarcolemmal, but not in interfibrillar cardiomyocyte mitochondria

Kerstin Boengler et al.

BASIC RESEARCH IN CARDIOLOGY (2009)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Remote ischaemic preconditioning reduces myocardial injury in patients undergoing cardiac surgery with cold-blood cardioplegia: a randomised controlled trial

V. Venugopal et al.

HEART (2009)

添加到收藏夹

Review Biochemistry & Molecular Biology

Mitochondria in cardiomyocyte Ca2+ signaling

Valedy Lukyanenko et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2009)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Activation of the protective Survivor Activating Factor Enhancement (SAFE) pathway against reperfusion injury: Does it go beyond the RISK pathway?

Sandrine Lecour

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2009)

添加到收藏夹

Article Multidisciplinary Sciences

Function of Mitochondrial Stat3 in Cellular Respiration

Joanna Wegrzyn et al.

SCIENCE (2009)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Signal transducer and activator of transcription 3 is involved in the cardioprotective signalling pathway activated by insulin therapy at reperfusion

Britt N. Fuglesteg et al.

BASIC RESEARCH IN CARDIOLOGY (2008)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Cardioprotection by ischemic postconditioning is lost in aged and STAT3-deficient mice

Kerstin Boengler et al.

CIRCULATION RESEARCH (2008)

添加到收藏夹

Review Pharmacology & Pharmacy

The myocardial JAK/STAT pathway: From protection to failure

Kerstin Boengler et al.

PHARMACOLOGY & THERAPEUTICS (2008)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Heart mitochondria:: gates of life and death

Asa B. Gustafsson et al.

CARDIOVASCULAR RESEARCH (2008)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Endothelial STAT3 plays a critical role in generalized myocardial proinflammatory and proapoptotic signaling

Meijing Wang et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2007)

添加到收藏夹

Article Medicine, General & Internal

Effect of remote ischaemic preconditioning on myocardial injury in patients undergoing coronary artery bypass graft surgery: a randomised controlled trial

Derek J. Hausenloy et al.

LANCET (2007)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Survival pathways in hypertrophy and heart failure: The gp130-STAT3 axis

Philipp Fischer et al.

BASIC RESEARCH IN CARDIOLOGY (2007)

添加到收藏夹

Article Biochemistry & Molecular Biology

A cathepsin D-cleaved 16 kDa form of prolactin mediates postpartum cardiomyopathy

Denise Hilfiker-Kleiner et al.

CELL (2007)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Role of the protein kinase C-←Raf-1-MEK-1/2-p44/42 MAPK signaling cascade in the activation of signal transducers and activators of transcription 1 and 3 and induction of cyclooxygenase-2 after ischemic preconditioning

YT Xuan et al.

CIRCULATION (2005)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

New directions for protecting the heart against ischaemia-reperfusion injury: targeting the Reperfusion Injury Salvage Kinase (RISK)-pathway

DJ Hausenloy et al.

CARDIOVASCULAR RESEARCH (2004)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

STAT signaling in ischemic heart: a role of STAT5A in ischemic preconditioning

G Yamaura et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2003)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Appearance of an erythrocyte population with decreased deformability and hemoglobin content following sepsis

MR Condon et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2003)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.