An integrated analysis of dysregulated SCD1 in human cancers and functional verification of miR-181a-5p/SCD1 axis in esophageal squamous cell carcinoma

Article Biotechnology & Applied Microbiology

MiR-181a-5p facilitates proliferation, invasion, and glycolysis of breast cancer through NDRG2-mediated activation of PTEN/AKT pathway

Zhen Zhai et al.

Summary: miR-181a-5p facilitates tumor progression by activating the PTEN/AKT signaling pathway through its regulation of NDRG2.

BIOENGINEERED (2022)

添加到收藏夹

Article Cell Biology

MicroRNA-181a-5p prevents the progression of esophageal squamous cell carcinoma in vivo and in vitro via the MEK1-mediated ERK-MMP signaling pathway

Mingbo Wang et al.

Aging-US (2022)

添加到收藏夹

Article Oncology

Carcinoma-associated fibroblasts release microRNA-331-3p containing extracellular vesicles to exacerbate the development of pancreatic cancer via the SCARA5-FAK axis

Yadong Han et al.

Summary: miR-331-3p in CAFs-derived EVs enhances the proliferative, migrating, and invasive potentials of PC cells and promotes tumor growth by manipulating the SCARA5/FAK axis.

CANCER BIOLOGY & THERAPY (2022)

添加到收藏夹

Article Oncology

DRP1 contributes to head and neck cancer progression and induces glycolysis through modulated FOXM1/MMP12 axis

Tai-Lin Huang et al.

Summary: The study found that upregulation of DRP1 in head and neck cancer tissues is associated with poor patient prognosis; The mechanisms by which DRP1 affects HNC development include influencing aerobic glycolysis by regulating glycolytic genes and modulating FOXM1 and MMP12 expression; miR-575 can suppress DRP1 expression by targeting its mRNA.

MOLECULAR ONCOLOGY (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Sex differences in esophageal cancer overall and by histological subtype

Nickolas Stabellini et al.

Summary: Esophageal cancer is the seventh most common type of cancer worldwide and the sixth leading cause of cancer-related death. The incidence of esophageal cancer is higher in males, but there is limited data on prognosis and survival. This study aimed to analyze the differences between sexes and other factors in patients with primary esophageal cancer. The analysis of data from 2005 to 2020 showed differences between males and females in age at diagnosis, histology, smoking status, and prescriptions of NSAIDs. However, there was no significant difference in survival between males and females.

SCIENTIFIC REPORTS (2022)

添加到收藏夹

Article Oncology

Aberrant miR-874-3p/leptin/EGFR/c-Myc signaling contributes to nasopharyngeal carcinoma pathogenesis

Sheng-Dean Luo et al.

Summary: Leptin is highly expressed in patients with nasopharyngeal carcinoma, promoting cell growth and invasion by regulating cell cycle, glycolysis, and EGFR signaling. miR-874-3p influences the progression of NPC by modulating Leptin expression, affecting cell growth, motility, and metabolism.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2022)

添加到收藏夹

Article Oncology

Azelnidipine inhibits esophageal squamous cell carcinoma proliferation in vivo and in vitro by targeting MEK1/2

Lili Zhao et al.

Summary: Azelnidipine, a calcium channel blocker, was found to inhibit the growth of esophageal squamous cell carcinoma (ESCC) by suppressing the kinase activity of MEK1/2.

MOLECULAR THERAPY-ONCOLYTICS (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

Stearoyl-CoA desaturase 1 as a therapeutic target for cancer: a focus on hepatocellular carcinoma

Mortaza Raeisi et al.

Summary: One of the main characteristics of cancer cells is the alteration in lipid composition, particularly the enrichment of monounsaturated fatty acids (MUFAs). The enzyme stearoyl CoA desaturase (SCD1), which converts saturated fatty acids to monounsaturated fatty acids, is overexpressed in various cancer cells and is associated with cancer aggressiveness and poor patient outcome. SCD1 also plays a role in cancer cell proliferation, migration, chemoresistance, and maintenance of cancer stem cells properties. Therefore, SCD1 may be a potential therapeutic target in hepatocellular carcinoma (HCC) and other cancers.

MOLECULAR BIOLOGY REPORTS (2022)

添加到收藏夹

Article Oncology

Targeting stearoyl-coa desaturase enhances radiation induced ferroptosis and immunogenic cell death in esophageal squamous cell carcinoma

Hui Luo et al.

Summary: This study found that targeting SCD1 can increase the sensitivity of esophageal squamous cell carcinoma (ESCC) to radiation therapy and induce ferroptosis and immunogenic cell death (ICD). Inhibition of SCD1 can improve radiation resistance in ESCC cells and has potential clinical applications.

ONCOIMMUNOLOGY (2022)

添加到收藏夹

Article Cell Biology

p73α1, an Isoform of the p73 Tumor Suppressor, Modulates Lipid Metabolism and Cancer Cell Growth via Stearoyl-CoA Desaturase-1

Zachary Rabow et al.

Summary: p73 alpha 1 alters lipid metabolism in non-small cell lung carcinoma cells by suppressing the expression of genes involved in phosphatidylcholine synthesis and inhibiting the activity of SCD1, leading to changes in the levels of phosphatidylcholines containing saturated fatty acids and monounsaturated fatty acids, as well as the ratio of saturated fatty acids to monounsaturated fatty acids.

CELLS (2022)

添加到收藏夹

Article Oncology

TCL1A acts as a tumour suppressor by modulating gastric cancer autophagy via miR-181a-5p-TCL1A-Akt/mTOR-c-MYC loop

Jialing Hao et al.

Summary: TCL1A regulates autophagy through the miR-181a-5p-TCL1A-Akt/mTOR-c-MYC loop, exerting a tumor suppressive effect and potentially serving as a therapeutic target for gastric cancer.

CARCINOGENESIS (2022)

添加到收藏夹

Article Medical Laboratory Technology

Exosomal noncoding RNAs in prostate cancer

Ahmad Movahedpour et al.

Summary: This article reviewed the importance and roles of exosomal ncRNAs in prostate cancer (PCa), with a focus on different miRNAs and lncRNAs found in various liquid samples that can serve as biomarkers for PCa diagnosis.

CLINICA CHIMICA ACTA (2022)

添加到收藏夹

Article Medicine, General & Internal

microRNA-181a-5p impedes the proliferation, migration, and invasion of retinoblastoma cells by targeting the NRAS proto-oncogene

Ming Ouyang et al.

Summary: miR-181a-5p expression was decreased in RB tissues and cell lines, and it suppressed the malignant behaviors of RB cells by targeting NRAS.

CLINICS (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

KRAS Affects Adipogenic Differentiation by Regulating Autophagy and MAPK Activation in 3T3-L1 and C2C12 Cells

Wenjie Yu et al.

Summary: In this study, it was found that inhibition of KRAS in 3T3-L1 and C2C12 cells altered the expression of key proteins involved in cell proliferation, autophagy, and adipogenic differentiation, leading to reduced proliferation capacity, enhanced differentiation into mature adipocytes, and increased lipid accumulation. Additionally, KRAS inhibition decreased the activation levels of several signaling pathways during differentiation. These results demonstrate the unique regulatory effects of KRAS on cell processes related to adipogenesis and lipid accumulation.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

FBW7-NRA41-SCD1 axis synchronously regulates apoptosis and ferroptosis in pancreatic cancer cells

Zeng Ye et al.

Summary: FBW7 acts as a tumor suppressor by targeting oncoproteins for degradation in pancreatic cancer, with decreased expression leading to destabilization and activation of pathways like ferroptosis and apoptosis which inhibit tumor growth, suggesting potential new strategies for comprehensive treatment of pancreatic cancer.

REDOX BIOLOGY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Mechanisms of stearoyl CoA desaturase inhibitor sensitivity and acquired resistance in cancer

Nicole Oatman et al.

Summary: In glioblastoma, some patients have low levels of SCD expression, leading to the evolution of cell lines that can survive independent of SCD, despite unknown mechanisms. Cell lines that escape genetic and epigenetic alterations become highly dependent on SCD for survival. Resistance to SCD inhibition in SCD-dependent lines is mediated through a previously unknown FOSB mechanism, which can be blunted to extend survival in tumor-bearing mice.

SCIENCE ADVANCES (2021)

添加到收藏夹

Review Oncology

MicroRNAs in the Pathogenesis of Hepatocellular Carcinoma: A Review

Asahiro Morishita et al.

Summary: Hepatocellular carcinoma (HCC) is a common and deadly cancer, with a poor prognosis in late stages. Understanding the role of microRNAs (miRNAs) in HCC pathogenesis may lead to improved outcomes. MiRNAs have potential as valuable biomarkers and therapeutic targets in HCC diagnosis and treatment.

CANCERS (2021)

添加到收藏夹

Article Oncology

Regulatory Interplay between miR-181a-5p and Estrogen Receptor Signaling Cascade in Breast Cancer

Rosaria Benedetti et al.

Summary: Despite significant efforts in breast cancer care, variations in patient survival rates and treatment response remain major challenges. Epigenetic-based reprogramming offers a promising strategy to combat breast cancer independently from acquired resistance mechanisms induced by prolonged therapy. The interplay between miR-181a-5p and Estrogen Receptor alpha has shown potential in regulating breast cancer progression and treatment sensitivity.

CANCERS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

MicroRNA Expression Profiles in Superficial Esophageal Squamous Cell Carcinoma before Endoscopic Submucosal Dissection: A Pilot Study

Shintaro Fujihara et al.

Summary: Esophageal squamous cell carcinoma (ESCC) requires early detection and treatment for improved survival, but diagnosis can be challenging due to observer variation. Studies have shown significant dysregulation of miRNA expression in superficial ESCC, particularly with miR-21-5p, miR-146b-5p, and miR-210-3p. These miRNAs are associated with ESCC invasion depth and lymphovascular invasion.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Article Cell Biology

Modulation of SCD1 activity in hepatocyte cell lines: evaluation of genomic stability and proliferation

Arthur Cassio de Lima Luna et al.

Summary: SCD1 plays a crucial role in hepatocarcinogenesis by affecting cell proliferation, survival, and genomic stability. This study found that SCD1 overexpression or MUFA stimulation can enhance cell proliferation and survival, while SCD1 inhibitor has the opposite effects.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2021)

添加到收藏夹

Review Oncology

SCD1, autophagy and cancer: implications for therapy

Francesca Ascenzi et al.

Summary: Autophagy is an intracellular degradation system that interacts with lipid metabolism, where fatty acids play a crucial role. SCD1 plays a significant role in promoting cell proliferation and metastasis in cancer, but its role in autophagy remains controversial, potentially resulting in either cancer promotion or inhibition depending on cancer heterogeneity and plasticity.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

添加到收藏夹

Review Oncology

Modern Diagnosis of Early Esophageal Cancer: From Blood Biomarkers to Advanced Endoscopy and Artificial Intelligence

Pierfrancesco Visaggi et al.

Summary: Esophageal cancer (EC) has a poor prognosis when the diagnosis is delayed, but curative treatment is possible if diagnosed early. Blood biomarkers, advanced endoscopy, and artificial intelligence are current options for early diagnosis of EC.

CANCERS (2021)

添加到收藏夹

Article Medicine, Research & Experimental

Discovery of extracellular vesicles derived miR-181a-5p in patient's serum as an indicator for bone-metastatic prostate cancer

Yanqing Wang et al.

Summary: The study identified miR-181a-5p as a potential diagnostic biomarker for bone-metastatic prostate cancer in EVs from patient's serum, with significantly upregulated expression in bone metastatic groups compared to non-bone metastatic groups. Logistic regression and AUC analysis confirmed miR-181a-5p as the best biomarker for diagnosing both prostate cancer and bone metastatic prostate cancer.

THERANOSTICS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Stearoyl-CoA desaturase and tumorigenesis

Kohtaro Kikuchi et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2020)

添加到收藏夹

Article Cell Biology

Overexpression of miR-181a-5p inhibits retinal neovascularization through endocan and the ERK1/2 signaling pathway

Xiuping Chen et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

SCD1 promotes lipid mobilization in subcutaneous white adipose tissue

Ying Zou et al.

JOURNAL OF LIPID RESEARCH (2020)

添加到收藏夹

Article Cell Biology

LncRNA LUCAT1/miR-181a-5p axis promotes proliferation and invasion of breast cancer via targeting KLF6 and KLF15

Yun Liu et al.

BMC MOLECULAR AND CELL BIOLOGY (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Oncogenic activation of PI3K-AKT-mTOR signaling suppresses ferroptosis via SREBP-mediated lipogenesis

Junmei Yi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

添加到收藏夹

Article Cell Biology

LncRNA LHFPL3-AS1 contributes to tumorigenesis of melanoma stem cells via the miR-181a-5p/BCL2 pathway

Song Zhang et al.

CELL DEATH & DISEASE (2020)

添加到收藏夹

Article Oncology

SCD1 is required for EGFR-targeting cancer therapy of lung cancer via re-activation of EGFR/PI3K/AKT signals

Kelin She et al.

CANCER CELL INTERNATIONAL (2019)

添加到收藏夹

Article Oncology

Stearoyl-CoA Desaturase 1 Protects Ovarian Cancer Cells from Ferroptotic Cell Death

Lia Tesfay et al.

CANCER RESEARCH (2019)

添加到收藏夹

Review Oncology

Stearoyl-CoA Desaturase 1 as a Therapeutic Target for the Treatment of Cancer

Zuzanna Tracz-Gaszewska et al.

CANCERS (2019)

添加到收藏夹

Article Cell Biology

The MYC Oncogene Cooperates with Sterol-Regulated Element-Binding Protein to Regulate Lipogenesis Essential for Neoplastic Growth

Arvin M. Gouw et al.

CELL METABOLISM (2019)

添加到收藏夹

Editorial Material Oncology

Stearoyl CoA Desaturase Regulates Ferroptosis in Ovarian Cancer Offering New Therapeutic Perspectives

Michele Carbone et al.

CANCER RESEARCH (2019)

添加到收藏夹

Article Cell Biology

Inhibition of stearoyl CoA desaturase-1 activity suppresses tumour progression and improves prognosis in human bladder cancer

Chiyuan Piao et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2019)

添加到收藏夹

Article Medicine, General & Internal

Development and Validation of an Esophageal Squamous Cell Carcinoma Detection Model by Large-Scale MicroRNA Profiling

Kazuki Sudo et al.

JAMA NETWORK OPEN (2019)

添加到收藏夹

Article Oncology

A mutational signature associated with alcohol consumption and prognostically significantly mutated driver genes in esophageal squamous cell carcinoma

X. C. Li et al.

ANNALS OF ONCOLOGY (2018)

添加到收藏夹

Article Medicine, Research & Experimental

IRE1α RNase-dependent lipid homeostasis promotes survival in Myc-transformed cancers

Hong Xie et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

添加到收藏夹

Article Oncology

Stearoyl-CoA desaturase-1 promotes colorectal cancer metastasis in response to glucose by suppressing PTEN

Hui Ran et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Lung fibroblasts promote metastatic colonization through upregulation of stearoyl-CoA desaturase 1 in tumor cells

Guanghua Liu et al.

ONCOGENE (2018)

添加到收藏夹

Article Cell Biology

MicroRNA-181a promotes angiogenesis in colorectal cancer by targeting SRCIN1 to promote the SRC/VEGF signaling pathway

Wu Sun et al.

CELL DEATH & DISEASE (2018)

添加到收藏夹

Article

Targeting stearoyl-CoA desaturase 1 to repress endometrial cancer progression

Weihua Li et al.

Oncotarget (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

EGFR modulates monounsaturated fatty acid synthesis through phosphorylation of SCD1 in lung cancer

Jiqin Zhang et al.

MOLECULAR CANCER (2017)

添加到收藏夹

Review Biotechnology & Applied Microbiology

MicroRNA therapeutics: towards a new era for the management of cancer and other diseases

Rajesha Rupaimoole et al.

NATURE REVIEWS DRUG DISCOVERY (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Stearoyl-CoA-desaturase 1 regulates lung cancer stemness via stabilization and nuclear localization of YAP/TAZ

A. Noto et al.

ONCOGENE (2017)

添加到收藏夹

Article Oncology

miR-181a-5p, an inducer of Wnt-signaling, facilitates cell proliferation in acute lymphoblastic leukemia

Xiaoming Lyu et al.

ONCOLOGY REPORTS (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Oncogene KRAS activates fatty acid synthase, resulting in specific ERK and lipid signatures associated with lung adenocarcinoma

Arvin M. Gouw et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

添加到收藏夹

Review Endocrinology & Metabolism

Insights into Stearoyl-CoA Desaturase-1 Regulation of Systemic Metabolism

Ahmed M. ALjohani et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2017)

添加到收藏夹

Article Oncology

miR-181a-5p promotes the progression of gastric cancer via RASSF6-mediated MAPK signalling activation

Yushuai Mi et al.

CANCER LETTERS (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

MicroRNA-181a-5p enhances cell proliferation in medullary thymic epithelial cells via regulating TGF-β signaling

Dongguang Guo et al.

ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2016)

添加到收藏夹

Article Biochemistry & Molecular Biology

Effects of Kras activation and Pten deletion alone or in combination on MUC1 biology and epithelial-to-mesenchymal transition in ovarian cancer

L. Zhang et al.

ONCOGENE (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Stearoyl-CoA desaturase-1 mediated cell apoptosis in colorectal cancer by promoting ceramide synthesis

Ling Chen et al.

SCIENTIFIC REPORTS (2016)

添加到收藏夹

Article Endocrinology & Metabolism

Inhibition of stearoyl-CoA desaturase-1 in differentiating 3T3-L1 preadipocytes upregulates elongase 6 and downregulates genes affecting triacylglycerol synthesis

J. C. Ralston et al.

INTERNATIONAL JOURNAL OF OBESITY (2014)

添加到收藏夹

Article Multidisciplinary Sciences

Alteration of the lipid profile in lymphomas induced by MYC overexpression

Livia S. Eberlin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

添加到收藏夹

Article Gastroenterology & Hepatology

Unsaturated fatty acids promote hepatoma proliferation and progression through downregulation of the tumor suppressor PTEN

Manlio Vinciguerra et al.

JOURNAL OF HEPATOLOGY (2009)

添加到收藏夹

An integrated analysis of dysregulated SCD1 in human cancers and functional verification of miR-181a-5p/SCD1 axis in esophageal squamous cell carcinoma

相关参考文献

导出引文

分享论文