4.6 Article

Synthesis of 3-arylindole derivatives from nitroalkane precursors

期刊

RSC ADVANCES
卷 6, 期 98, 页码 96049-96056

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ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ra21144e

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  1. Ministry of Science and Technology of the Republic of China [MOST 103-2113-M-003-008-MY3]
  2. National Taiwan Normal University [103-07-C]
  3. Instrumentation Centre at National Taiwan Normal University

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3-Arylindole derivatives were synthesized by Cu(I) catalysed intramolecular Ullmann coupling of 2-bromoarylaminoalkanes. 2-Bromoarylaminoalkanes were synthesized from 2-bromoarylnitroalkanes, which in turn prepared through AlCl3-mediated Friedel-Crafts alkylation of bromo-substituted beta-nitrostyrenes and arenes.

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