Three-Component Synthesis of Quinoline-4-carboxylic Acids Based on Doebner Hydrogen-Transfer Reaction

The Doebner hydrogen-transfer reaction has been developed for the synthesis of substituted quinolines from anilines possessing electron-withdrawing groups, which are known to give products in low yields when used in the conventional Doebner reaction. This reaction can be applied to not only anilines having electron-withdrawing groups but also those having electron-donating groups and can be used in the large-scale synthesis of bioactive molecules.

Automated summary

The Doebner hydrogen-transfer reaction has been developed as a method for synthesizing substituted quinolines from anilines with electron-withdrawing groups, which typically yield low product yields in conventional Doebner reactions. This reaction can be applied to anilines with both electron-withdrawing and electron-donating groups, making it useful for large-scale synthesis of bioactive molecules.