期刊
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
卷 16, 期 4, 页码 503-511出版社
ELSEVIER INC
DOI: 10.1016/j.jcmgh.2023.07.001
关键词
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Emerging evidence highlights the importance of the tumor microenvironment and cancer-associated fibroblasts (CAFs) in tumorigenesis and progression. CAFs secrete soluble factors and remodel the extracellular matrix, playing crucial roles in tumor development and therapeutic response. However, the limited understanding of CAF heterogeneity poses challenges for targeting CAFs clinically.
Emerging evidence has shown the importance of the tumor microenvironment in tumorigenesis and progression. Cancer-associated fibroblasts (CAFs) are one of the most infiltrated stroma cells of the tumor microenvironment in gastrointestinal tumors. CAFs play crucial roles in tumor development and therapeutic response by biologically secreting soluble factors or structurally remodeling the extracellular matrix. Conceivably, CAFs may become excellent targets for tumor prevention and treatment. However, the limited knowledge of the heterogeneity of CAFs represents a huge challenge for clinically targeting CAFs. In this review, we summarize the newest understanding of gastrointestinal CAFs, with a special focus on their origin, differentiation, and function. We also discuss the current understanding of CAF subpopulations as shown by single-cell technologies.
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