A catalyst-free approach to 3-thiocyanato-4H-chromen-4-ones

A facile and efficient approach to 3-thiocyanato-4H-chromen-4-ones was realized at room temperature. In the presence of KSCN and K2S2O8, various enaminones underwent thiocyanation and cyclization, affording 3-thiocyanatochromenones in good yields. In addition, one-pot synthesis of 3-thiocyanatochromenones from 2-hydroxylacetophenones was also developed.