期刊
RSC ADVANCES
卷 6, 期 52, 页码 46972-46976出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ra02347a
关键词
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资金
- Fundacao para a Ciencia e Tecnologia (FCT) [QUI/UI0081/2015-POCI-01-0145-FEDER-006980]
- Angeles Alvarino, Plan Galego de Investigacion, Innovacion e Crecemento [I2C]
- FCT
- POPH
- QREN [SFRH/BPD/74491/2010, SFRH/BPD/93331/2013, SFRH/BD/96033/2013]
The first potent and selective hA(1)AR ligand based on the chromone scaffold is reported in this work. Receptor-driven molecular modeling studies provide valuable information about the molecular interactions responsible for the high affinity of N-(2-nitrophenyl)-4-oxo-4H-chromene-2-carboxamide to the hA(1)AR (K-i = 0.219 mu M) and reinforce the crucial role of AR affinity of the amide linker located at C-2 of the pyrone ring.
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