The emerging complexity of molecular pathways implicated in mouse self-grooming behavior

Rodent self-grooming is an important complex behavior, and its deficits are translationally relevant to a wide range of neuropsychiatric disorders. Here, we analyzed a comprehensive dataset of 227 genes whose mutations are known to evoke aberrant self-grooming in mice. Using these genes, we constructed the network of their established protein-protein interactions (PPI), yielding several distinct molecular clusters related to postsynaptic density, the Wnt signaling, transcription factors, neuronal cell cycle, NOS neurotransmission, microtubule regulation, neuronal differentiation/trafficking, neurodevelopment and mitochondrial function. Utilizing further bioinformatics analyses, we also identified novel central ('hub') proteins within these clusters, whose genes may also be implicated in aberrant self-grooming and other repetitive behaviors in general. Untangling complex molecular pathways of this important behavior using in silico approaches contributes to our understanding of related neurological disorders, and may suggest novel potential targets for their pharmacological or gene therapy.

Automated summary

This study analyzed a dataset of 227 genes, whose mutations can cause abnormal self-grooming in mice. Through the construction of a protein-protein interaction network, several molecular clusters related to various cellular processes were identified. Further bioinformatics analyses revealed key hub proteins within these clusters, which may be implicated in aberrant self-grooming and repetitive behaviors. Understanding the complex molecular pathways of this important behavior contributes to the understanding and potential treatment of related neurological disorders.