Improvement in OCD symptoms associated with serotoninergic psychedelics: a retrospective online survey

A renewed interest in the use of psychedelics for treating obsessive compulsive disorder (OCD) has emerged in the last 20 years. But pre-clinical and clinical evidence remain scarce, and little is known about the factor determining the magnitude and persistence of the therapeutic effect. We therefore designed a retrospective online survey to explore, in the general population using psychoactive drugs, their impact on OCD symptoms. We also assessed the attitude of the participants towards the substance in term of frequency of intakes. In a sample of 174 participants, classic psychedelics were reported as the only substances effective at reducing OCD symptoms. In classic psychedelics users, symptoms reduction was associated with the intensity of acute effects, itself correlated to the dose. Reports on the persistence of the therapeutic effect varied from weeks to months, but we could not find any predicting factor. Finally, the occurrence and frequency of subsequent intakes, which seemed to be limited in our sample, were predicted by the magnitude and persistence of the therapeutic effect, respectively. Our observations support the hypothesis of classic psychedelics efficacy in reducing OCD symptoms but a careful evaluation of the persistence of this effect is still needed.

Automated summary

There has been a renewed interest in using psychedelics to treat OCD in the past 20 years. However, there is limited pre-clinical and clinical evidence, and little is known about the factors that determine the magnitude and persistence of the therapeutic effect. A retrospective online survey was conducted to explore the impact of psychoactive drugs on OCD symptoms in the general population. The survey found that classic psychedelics were the only substances reported to be effective in reducing OCD symptoms.