期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 -, 期 -, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202310762
关键词
Bimetallic Relay; Difluoroalkylation; Difluoromethylation; Homogeneous Catalysis; Radical
In this paper, a novel bimetallic relay catalysis of Mn2(CO)10 and cobaloxime has been developed for the divergent dehydrogenative difluoroalkylation of alkenes using commercially available difluoroalkyl bromides. A wide range of structurally diverse difluoroalkylated allylic products and difluoromethylated cyclic products were efficiently synthesized, accompanied with the production of H2 as the by-product. This bimetallic relay strategy features broad substrate scope, mild reaction conditions, and excellent functional group compatibility.
The involvement of manganese radical for halogen atom transfer (XAT) reactions has been esteemed as one reliable method but encountered with limited catalytic models. In this paper, a novel bimetallic relay catalysis of Mn2(CO)10 and cobaloxime has been developed for divergent dehydrogenative difluoroalkylation of alkenes using commercially available difluoroalkyl bromides. A wide range of structurally diverse terminal, cyclic and internal alkenes as well as tetrasubstituted alkenes are found to be good coupling partners to deliver difluoroalkylated allylic products and difluoromethylated cyclic products, accompanied with the production of H2 as the by-product. This bimetallic relay strategy features broad substrate scope, mild reaction conditions and excellent functional group compatibility. Its success represents an important step-forward to expedite the construction of a rich library of difluoroalkylated products. A novel bimetallic relay catalysis of Mn2(CO)10 and cobaloxime has been developed for the divergent dehydrogenative difluoroalkylation of alkenes using commercially available difluoroalkyl bromides. A wide range of structurally diverse difluoroalkylated allylic products and difluoromethylated cyclic products were concisely constructed.image
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据