4.7 Article

Blockade of the mineralocorticoid receptor improves markers of human endothelial cell dysfunction and hematological indices in a mouse model of sickle cell disease

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Immunology

Blockade of endothelin-1 receptor B regulates molecules of the major histocompatibility complex in sickle cell disease

Yaritza Inostroza-Nieves et al.

Summary: A study found that Major Histocompatibility Complex (MHC) molecules play a role in Sickle Cell Disease (SCD) pathophysiology. Endothelial cells express MHC molecules after exposure to cytokines. SCD is characterized by vascular endothelial cell activation, oxidative stress, sickle cell adhesion, and excess levels of endothelin-1 (ET-1). The study suggests that ET-1 is a novel regulator of MHC class II molecules and ET-1 receptor blockade may be a promising therapeutic approach for regulating immune and vascular responses in SCD.

FRONTIERS IN IMMUNOLOGY (2023)

Review Urology & Nephrology

Considerations for the future: current and future treatment paradigms with mineralocorticoid receptor antagonists-unmet needs and underserved patient cohorts

Murray Epstein

Summary: The recent successful trials of finerenone in patients with chronic kidney disease and type 2 diabetes indicate the potential for future clinical trials in patients with non-diabetic kidney disease. The relationship between fibroblast growth factor 23, membrane Klotho, and aldosterone may also be a promising area of investigation.

KIDNEY INTERNATIONAL SUPPLEMENTS (2022)

Article Biochemistry & Molecular Biology

Magnesium homeostasis in deoxygenated sickle erythrocytes is modulated by endothelin-1 via Na+/Mg2+ exchange

Jose R. Romero et al.

Summary: Painful crises in sickle cell disease (SCD) are associated with increased plasma cytokines levels, including endothelin-1 (ET-1). This study found that ET-1 can increase Na+/Mg2+ exchanger (NME) activity in sickle red cells, leading to potassium loss, dehydration, and sickling. However, deoxygenation of sickle red cells decreased NME activity and caused cellular dehydration, which could be reversed by NME inhibitor, imipramine. Pre-incubation with ET-1 type B receptor blocker, BQ788, significantly blocked the increased NME activity in sickle red cells.

FASEB JOURNAL (2022)

Review Cardiac & Cardiovascular Systems

Steroidal and non-steroidal mineralocorticoid receptor antagonists in cardiorenal medicine

Rajiv Agarwal et al.

Summary: This review covers the development of mineralocorticoid receptor antagonists (MRAs) over the last 80 years, discussing the differences in mechanisms and effects between nonsteroidal and steroidal MRAs. Nonsteroidal MRAs demonstrate important distinctions in distribution, binding mode, and gene expression compared to steroidal MRAs.

EUROPEAN HEART JOURNAL (2021)

Article Cardiac & Cardiovascular Systems

Enhanced Thrombotic Responses Are Associated With Striatin Deficiency and Aldosterone

Anna Gromotowicz-Poplawska et al.

Summary: The deficiency of striatin is associated with an increased prothrombotic response, demonstrating its protective role in experimental thrombosis. This protective effect may be reduced in human striatin risk allele carriers, indicating potential implications in blood pressure regulation.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2021)

Review Pharmacology & Pharmacy

The Effect of Antihypertensive Medications on Testing for Primary Aldosteronism

Piotr Jedrusik et al.

Summary: Primary aldosteronism (PA) is a potentially curable form of secondary hypertension that requires measuring renin and aldosterone, followed by confirmatory tests. Various antihypertensive drug classes interfere with PA evaluation, with calcium antagonists and alpha-blockers being the least interfering drugs.

FRONTIERS IN PHARMACOLOGY (2021)

Article Peripheral Vascular Disease

Aldosterone contributes to hypertension in malemice inducibly overexpressing human endothelin-1 in endothelium

Olga Berillo et al.

Summary: The study found that overexpression of hET-1 in endothelial cells in mice leads to increased plasma aldosterone levels, which affects BP elevation and vascular injury. Aldosterone plays a crucial role in the effects induced by overexpression of hET-1 in endothelial cells.

JOURNAL OF HYPERTENSION (2021)

Article Urology & Nephrology

Aldosterone and Mineralocorticoid Receptor Signaling as Determinants of Cardiovascular and Renal Injury: From Hans Selye to the Present

Murray Epstein

Summary: Understanding the mechanisms of action of aldosterone and its interaction with the mineralocorticoid receptor (MR) provides a theoretical framework to predict the therapeutic potential of MR antagonists (MRAs) in CKD and heart failure. Recent studies have shown that aldosterone plays a wider role in modulating inflammation, collagen formation, fibrosis, and necrosis, beyond its initial focus on renal excretory function. Blockade of the MR is being investigated as a novel treatment to slow the progression of CKD, as demonstrated in the FIDELIO-DKD study.

AMERICAN JOURNAL OF NEPHROLOGY (2021)

Review Cardiac & Cardiovascular Systems

Steroidal and non-steroidal mineralocorticoid receptor antagonists in cardiorenal medicine

Rajiv Agarwal et al.

Summary: This review summarizes the development of mineralocorticoid receptor antagonists over the past 80 years, focusing on the mechanisms of action and advantages of nonsteroidal MRAs.

EUROPEAN HEART JOURNAL (2021)

Review Cardiac & Cardiovascular Systems

Sickle cell disease: at the crossroads of pulmonary hypertension and diastolic heart failure

Katherine C. Wood et al.

Article Cardiac & Cardiovascular Systems

A New Role for the Aldosterone/Mineralocorticoid Receptor Pathway in the Development of Mitral Valve Prolapse

Jaime Ibarrola et al.

CIRCULATION RESEARCH (2020)

Article Endocrinology & Metabolism

Striatin heterozygous mice are more sensitive to aldosterone-induced injury

Amanda E. Garza et al.

JOURNAL OF ENDOCRINOLOGY (2020)

Article Medicine, General & Internal

Effect of Finerenone on Chronic Kidney Disease Outcomes in Type 2 Diabetes

George L. Bakris et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Hematology

Inflammation in sickle cell disease

Nicola Conran et al.

CLINICAL HEMORHEOLOGY AND MICROCIRCULATION (2018)

Article Peripheral Vascular Disease

Biological Sex Modulates the Adrenal and Blood Pressure Responses to Angiotensin II

Mohammad Zaki Shukri et al.

HYPERTENSION (2018)

Article Endocrinology & Metabolism

Randomized, Placebo-Controlled Trial to Evaluate Effects of Eplerenone on Metabolic and Inflammatory Indices in HIV

Suman Srinivasa et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2018)

Article Medicine, Research & Experimental

Dysregulated aldosterone secretion in persons of African descent with endothelin-1 gene variants

Jia W. Tan et al.

JCI INSIGHT (2017)

Article Hematology

Losartan for the nephropathy of sickle cell anemia: A phase-2, multicenter trial

Charles T. Quinn et al.

AMERICAN JOURNAL OF HEMATOLOGY (2017)

Article Multidisciplinary Sciences

Sickle cell anemia mice develop a unique cardiomyopathy with restrictive physiology

Nihal Bakeer et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Review Urology & Nephrology

Sickle cell disease: renal manifestations and mechanisms

Karl A. Nath et al.

NATURE REVIEWS NEPHROLOGY (2015)

Review Hematology

The glomerulopathy of sickle cell disease

Kenneth I. Ataga et al.

AMERICAN JOURNAL OF HEMATOLOGY (2014)

Article Cardiac & Cardiovascular Systems

Antisickling fetal hemoglobin reduces hypoxia-inducible factor-1α expression in normoxic sickle mice: microvascular implications

Dhananjay K. Kaul et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2013)

Article Hematology

Molecular basis of erythrocyte adhesion to endothelial cells in diseases

Jean-Luc Wautier et al.

CLINICAL HEMORHEOLOGY AND MICROCIRCULATION (2013)

Article Peripheral Vascular Disease

Activation of the Mineralocorticoid Receptor Increases Striatin Levels

Luminita H. Pojoga et al.

AMERICAN JOURNAL OF HYPERTENSION (2012)

Review Cardiac & Cardiovascular Systems

Cardiovascular Abnormalities in Sickle Cell Disease

Mark T. Gladwin et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2012)

Review Cell Biology

Acute and chronic regulation of aldosterone production

Namita G. Hattangady et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2012)

Review Biochemistry & Molecular Biology

Endothelin-1 gene regulation

Lisa R. Stow et al.

FASEB JOURNAL (2011)

Article Biochemistry & Molecular Biology

Aldosterone Modulates Steroid Receptor Binding to the Endothelin-1 Gene (edn1)

Lisa R. Stow et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Review Cardiac & Cardiovascular Systems

A comparison of the aldosterone-blocking agents eplerenone and spironolactone

Allan Struthers et al.

CLINICAL CARDIOLOGY (2008)

Article Peripheral Vascular Disease

Aldosterone nongenomically produces NADPH oxidase-dependent reactive oxygen species and induces myocyte apoptosis

Hironori Hayashi et al.

HYPERTENSION RESEARCH (2008)

Review Medicine, General & Internal

Pulmonary Complications of Sickle Cell Disease.

Mark T. Gladwin et al.

NEW ENGLAND JOURNAL OF MEDICINE (2008)

Article Cell Biology

Reduced sickle erythrocyte dehydration in vivo by endothelin-1 receptor antagonists

Alicia Rivera

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2007)

Article Biochemistry & Molecular Biology

Protective effect of arginine on oxidative stress in transgenic sickle mouse models

Trisha Dasgupta et al.

FREE RADICAL BIOLOGY AND MEDICINE (2006)

Article Physiology

Protective effects of S-nitrosoalbumin on lung injury induced by hypoxia-reoxygenation in mouse model of sickle cell disease

Lucia de Franceschi et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2006)

Article Cardiac & Cardiovascular Systems

Inhibition of sickle red cell adhesion and vasoocclusion in the microcirculation by antioxidants

Dhananjay K. Kaul et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2006)

Article Medicine, General & Internal

Rates of hyperkalemia after publication of the randomized aldactone evaluation study

DN Juurlink et al.

NEW ENGLAND JOURNAL OF MEDICINE (2004)

Article Peripheral Vascular Disease

Cardiac damage prevention by eplerenone: Comparison with low sodium diet or potassium loading

DV Martinez et al.

HYPERTENSION (2002)

Article Cardiac & Cardiovascular Systems

The endothelin-aldosterone axis and cardiovascular diseases

GP Rossi et al.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2001)

Article Peripheral Vascular Disease

Aldosterone receptor antagonism normalizes vascular function in liquorice-induced hypertension

T Quaschning et al.

HYPERTENSION (2001)

Review Urology & Nephrology

Renoprotective benefits of RAS inhibition: From ACEI to angiotensin II antagonists

MW Taal et al.

KIDNEY INTERNATIONAL (2000)

Article Urology & Nephrology

Specificity in mineralocorticoid versus glucocorticoid action

PJ Fuller et al.

KIDNEY INTERNATIONAL (2000)