Metal-free reusable hollow-spherical triazine microporous organic polymer supported quinolines synthesis via hydrogen evolution

In the synthesis of medicinally and industrially valuable quinoline scaffolds, we report a one-pot greener synthetic route to do away with harsh reaction conditions, low productivity, and unstable substrates associated with the classical methods reported in the literature. Readily available alcohols undergo acceptorless dehydrogenative annulation in basic media over an engineered nitrogen-rich hollow-spherical microporous polymer (MOP-TA) devoid of any metal support. This affordable and sustainable route stands up to the test of scalability and green matrices, which are supported by various spectroscopic and microscopic techniques.

Automated summary

We present a greener synthetic route for the synthesis of medicinally and industrially valuable quinoline scaffolds, eliminating harsh reaction conditions, low productivity, and unstable substrates associated with classical methods. This route involves the acceptorless dehydrogenative annulation of readily available alcohols in basic media using an engineered nitrogen-rich hollow-spherical microporous polymer (MOP-TA) without any metal support. The scalability and green matrices of this affordable and sustainable route are supported by various spectroscopic and microscopic techniques.