期刊
RSC ADVANCES
卷 6, 期 10, 页码 8021-8031出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ra22445d
关键词
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资金
- CAPES
- CNPq [306430/2013-4, 400150/2014-0, 447595/2014-8]
- FAPESP [15/17141-1, 14/50249-8]
- FINEP
- FAPERGS
We describe herein our results on the synthesis, antioxidant properties and chemical diversification of phenylselanyl-1H-1,2,3-triazole-4-carbonitriles. These compounds were synthesized in high yields by the reaction of azidophenyl phenylselenides with a range of alpha-keto nitriles, using DMSO as the solvent in the presence of a catalytic amount of Et2NH (1 mol%). The synthesized compounds were screened for their in vitro antioxidant activity and 5-phenyl-1-(2-(phenylselanyl) phenyl)-1H-1,2,3-triazole-4-carbonitrile (3a) exhibited the highest antioxidant effect. In addition, the obtained triazoyl carbonitriles were readily transformed into more complex products via a cycloaddition protocol with NaN3, affording bifunctional hybrids containing triazole and tetrazole systems in good to excellent yields.
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