期刊
RSC ADVANCES
卷 6, 期 37, 页码 30895-30904出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ra26092b
关键词
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资金
- National Key Basic Research Program of China (973 Program) [2012CB721005, 2013CB734002]
- Joint Research Fund for Overseas Chinese, Hong Kong and Macao Young Scholars [31329005]
- State Key Program of National Natural Science Foundation of China [81530091]
- NIH [R01AI097260]
- Natural Science Foundation of Shandong Province, China [ZR2013HQ048]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT13028]
- National Natural Science Funds for Distinguished Young Scholars [30325044]
Heat-stable antifungal factor (HSAF) belongs to polycyclic tetramate macrolactams (PTMs), which inhibits many fungal pathogens and is effective in inhibiting Candida albicans (C. albicans). In this study, we found that HSAF induced the apoptosis of C. albicans SC5314 through inducing the production of reactive oxygen species (ROS). Nevertheless, we validated the efficacy of HSAF against candidiasis caused by C. albicans in a murine model in vivo, and HSAF significantly improved survival and reduced fungal burden compared to vehicles. A molecular dynamics (MD) simulation was also investigated, revealing the theoretical binding mode of HSAF to the beta-tubulin of C. albicans. This study first found PTMs-induced fungal apoptosis through ROS accumulation in C. albicans and its potential as a novel agent for fungicides.
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