Nontoxic and renewable metal-organic framework based on α-cyclodextrin with efficient drug delivery

A novel alpha-cyclodextrin based metal-organic framework (CD-MOF) with chiral helices, K-3(C36H60O30)(2)center dot 7H(2)O (1), was synthesized by vapor diffusion method, which contains infinitely long left-handed helical chains, interdigitated with six circumambient helical chains. Compound 1 exhibits efficient drug loading capacity and excellent sustained release behavior. In addition, by changing the synthetic method, another compound based on alpha-cyclodextrin, (C36H60O30)center dot H2O (2), was isolated by solvothermal synthesis, which contains left-handed chiral helical double channels, linked with adjacent four same helical channels. Moreover, the lower cytotoxicity of the two compounds indicates that they are a type of renewable, environmentally friendly and biocompatible drug carrier material.