Double-mode detection of HClO by naked eye and concurrent fluorescence increasing in absolute PBS

A water soluble fluorescent probe WCN was successfully designed and synthesized based on acenaphthenequinone. It can be employed for double-mode detection of HClO by the naked eye and concurrent significant fluorescence increasing in absolute PBS. The detection limit was measured down to 77 pM. Especially important, WCN works well in both living cells and a living mouse.