期刊
ONCOTARGET
卷 7, 期 48, 页码 80008-80018出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.13243
关键词
double-targeted; nanoparticles; antitumor; ultrasound contrast enhanced imaging; pancreatic cancer
资金
- Department of Ultrasound, Shanghai First People's Hospital Affiliated to Shanghai Jiao tong University School of Medicine (Shanghai, China)
- National Natural Science Foundation of China [81271596, 81171352, 81501483, 81502692]
A porous-structure nano-scale ultrasound contrast agent (UCA) was made of monomethoxypoly (ethylene glycol)-poly (lactic-co-glycolic acid) (mPEG-PLGA), and modified by double-targeted antibody: anti-carcinoembryonic antigen (CEA) and anti-carbohydrate antigen 19-9 (CA19-9), as a double-targeted nanoparticles (NPs). Anti-tumor drug paclitaxel (PTX) was encapsulated in the double-targeted nanoparticles (NPs). The morphor and release curve were characterized. We verified a certain anticancer effect of PTX-NPs through cytotoxicity experiments. The cell uptake result showed much more NPs may be facilitated to ingress the cells or tissues with ultrasound (US) or ultrasound targeted microbubble destruction (UTMD) transient sonoporation in vitro. Ultrasound contrast-enhanced images in vitro and in vivo were investigated. Compared with SonoVue, the NPs prolonged imaging time in rabbit kidneys and tumor of nude mice, which make it possible to further enhance antitumor effects by extending retention time in the tumor region. The novel doubletargeted NPs with the function of ultrasound contrast enhanced imaging and antitumor therapy can be a promising way in clinic.
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