期刊
ONCOTARGET
卷 7, 期 32, 页码 51473-51481出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.10444
关键词
long non-coding RNA; renal fibrosis; microRNA; unilateral ureteral obstruction
资金
- Shanghai Health and Family Planning Commission Project [201440384]
Although long non-coding RNAs (lncRNAs) are important players in the initiation and progression of many pathological processes, the role of lncRNAs in renal fibrosis still remains unclear. We showed that lncRNA-H19 expression was significantly upregulated in TGF-beta 2-induced HK-2 cell fibrosis and unilateral ureteral obstruction (UUO)-induced renal fibrosis in vivo. H19 knockdown significantly attenuated renal fibrosis in vitro and in vivo. LncRNA-H19, miR-17, and fibronectin constituted to a regulatory network involved in renal fibrosis. We also detected up-regulated H19 expression and down-regulated miR-17 expression in the early and advanced animal models of renal fibrosis. This study indicates that H19 up-regulation contributes to renal fibrosis. H19 inhibition might represent a novel anti-fibrotic treatment in renal diseases.
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