期刊
ONCOTARGET
卷 7, 期 50, 页码 82338-82353出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.11001
关键词
pancreatic ductal adenocarcinoma (PDAC); microRNA-891b (miR-891b); Cbl-b; prognosis; overall survival (OS)
资金
- Outstanding Scientific Fund of Shengjing Hospital [201210]
- National Science and Technology Major Project [2013ZX09303002]
- National Natural Science Foundation of China [81201615, 81372547]
- Science and Technology Plan Project of Liaoning Province [2014225013, 2015020457]
Growing evidence has revealed that microRNAs could regulate the proliferation of pancreatic ductal adenocarcinoma (PDAC) cells and predict the prognosis of PDAC. Here the comparative microRNA expression profiles of the good and poor prognosis groups were performed by microRNA microarray. MicroRNA-891b (miR-891b) was screened and validated to be a prognostic predictor of PDAC in the initial group and further evaluated to be an independent predictor for the overall survival of resectable PDACs in an independent cohort. By a series of cellular and animal experiments, as well as clinical specimen analyses, miR-891b was confirmed to target the Cbl-b gene, promot the expression of tumor suppressor p21 protein and inhibit the proliferation of PDAC cells. The results provide a theoretical basis for the study of miR-891b as an independent prognostic predictor of PDAC and the role of miR-891b/Cbl-b pathway in this prediction, as well as the identification of new targets for PDAC.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据