期刊
ONCOTARGET
卷 7, 期 19, 页码 27916-27925出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.8444
关键词
focused ultrasound; behavioral alterations; blood-brain barrier; memory; anxiety
资金
- Ministry of Science and Technology of Taiwan [MOST 104-2314-B-010-003-MY3, MOST 102-2221-E-010-005-MY3]
- Veterans General Hospitals University System of Taiwan Joint Research Program [VGHUST104-G7-6-1]
- Cheng Hsin General Hospital Foundation [CY10418, 103F003C17]
- Biophotonics & Molecular Imaging Research Center
- Biomedical Engineering Research and Development Center
The purpose of this study was to investigate the behavioral alterations and histological changes of the brain after FUS-induced BBB disruption (BBBD). Rats were behaviorally tested using the open field, hole-board, and grip strength tests from day 1 through day 32 after undergoing BBBD induced by FUS with either a mild or heavy parameter. In the open field test, we found an increase in center entries on day 1 and day 9 following heavy FUS treatment and a decrease in center entries at day 18 following mild FUS treatment. With regard to memory-related alterations, rats subjected to heavy FUS treatment exhibited longer latency to start exploring and to find the first baited hole. However, rats subjected to mild FUS treatment exhibited no significant differences in terms of memory performance or grip force. The obtained data suggest that heavy FUS treatment might induce hyperactivity, spatial memory impairment, and forelimb gripping deficits. Furthermore, while mild FUS treatment may have an impact on anxiety-related behaviors, the data suggested it had no impact on locomotor activity, memory, or grip force. Thus, the behavioral alterations following FUS-induced BBBD require further investigation before clinical application.
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