期刊
ONCOTARGET
卷 8, 期 1, 页码 1925-1936出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.12461
关键词
long non-coding RNAs; cancer; drug resistance; chemotherapy; targets
资金
- National Natural Science Foundation of China [81272601, 81472198]
- Key Clinical Medicine Technology Foundation of Jiangsu Province [BL2014096]
- Medical Key Talented Person Foundation of the Jiangsu Provincial Developing Health Project [RC2011080]
- Innovation Team Project of the Second Affiliated Hospital of Nanjing Medical University
- 333 high class Talented Man Project [2011-III-2630]
Chemotherapy is one of the basic treatments for cancers; however, drug resistance is mainly responsible for the failure of clinical treatment. The mechanism of drug resistance is complicated because of interaction among various factors including drug efflux, DNA damage repair, apoptosis and targets mutation. Long non-coding RNAs ( lncRNAs) have been a focus of research in the field of bioscience, and the latest studies have revealed that lncRNAs play essential roles in drug resistance in breast cancer, gastric cancer and lung cancer, et al. Dysregulation of multiple targets and pathways by lncRNAs results in the occurrence of chemoresistance. In this review, we will discuss the mechanisms underlying lncRNA-mediated resistance to chemotherapy and the therapeutic potential of lncRNAs in future cancer treatment.
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