期刊
ONCOTARGET
卷 7, 期 34, 页码 55863-55889出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.10150
关键词
regulated cell death; vacuolization; microbial toxins; viruses
资金
- Russian Science Foundation [14-14-00526]
- Russian Science Foundation [14-14-00526] Funding Source: Russian Science Foundation
Cytoplasmic vacuolization (also called cytoplasmic vacuolation) is a well-known morphological phenomenon observed in mammalian cells after exposure to bacterial or viral pathogens as well as to various natural and artificial low-molecular-weight compounds. Vacuolization often accompanies cell death; however, its role in cell death processes remains unclear. This can be attributed to studying vacuolization at the level of morphology for many years. At the same time, new data on the molecular mechanisms of the vacuole formation and structure have become available. In addition, numerous examples of the association between vacuolization and previously unknown cell death types have been reported. Here, we review these data to make a deeper insight into the role of cytoplasmic vacuolization in cell death and survival.
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