期刊
ONCOTARGET
卷 8, 期 3, 页码 5414-5425出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.14289
关键词
lymphocyte-to-monocyte ratio (LMR); neutrophil-to-lymphocyte ratio (NLR); diffuse large B-cell lymphoma (DLBCL); tumor-associated macrophages; programmed cell death-1 (PD-1)
资金
- National Natural Science Foundation of China [81472490]
The research aims to examine the prognostic value of the lymphocyte-tomonocyte ratio (LMR), neutrophil-to- lymphocyte ratio (NLR) and platelet-tolymphocyte ratio (PLR) in diffuse large B-cell lymphoma (DLBCL). The relation of these hematologic indicators to poor antitumor immunity and prognosis must be investigated. Clinicopathologic data and survival information of 355 patients with DLBCL was retrospectively analyzed. Univariate analysis revealed that lower LMR (< 2.71), higher NLR (>= 2.81), CD163+ M2 tumor-associated macrophages (TAM) content >= 9.5% and programmed cell death 1 (PD-1)+ tumor-infiltrating lymphocytes (TILs) content < 4.5 cells per high power field(HPF) were significantly related to unfavorable overall survival (OS) and progression free survival (PFS). When considering the prognostic indexes of IPI, multivariate analysis confirmed that LMR of < 2.71 and CD163(+) M2 TAM content >= 9.5% significantly affected the prognosis of DLBCL. Spearman correlation test showed LMR was negatively correlated with CD163(+) M2 TAM content. However, there were no correlation was found between LMR and PD-1+ TIL as well as between NLR and PD-1+ TIL content. These results indicated that decreased LMR lead to a weak anti-tumor immunity and could be used as a bad prognosis biomarker of DLBCL.
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