期刊
ONCOTARGET
卷 7, 期 52, 页码 86755-86765出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.13550
关键词
TRIM11; colon cancer; miR-24-3p
资金
- National Nature Science Foundation of China (NSFC) [81260337, 81660414, 81660449, 81460613, 81460430]
- Jiangxi Provincial Natural Science Foundation of China [20161ACB21001]
TRIM11 (tripartite motif-containing protein 11) is an E3 ubiquitin ligase recently identified as an oncogene in malignant glioma and lung cancer. In the present study, we report that expression of TRIM11 was increased in colon cancer (CC) tissue relative to paired normal tissues and that higher TRIM11 levels predicted poor overall survival (OS) and disease-free survival (DFS) in CC patients. Mechanistically, we showed that miR-24-3p downregulation contributes to TRIM11 upregulation in CC. We also demonstrated that TRIM11 overexpression promotes cell proliferation and colony formation and inhibits apoptosis in CC, while knocking down TRIM11 using CRISPR/Cas9-mediated genome editing inhibited cell proliferation and induced apoptosis. Silencing TRIM11 in vivo decreased tumor growth. These findings indicate that TRIM11 facilitates CC progression by promoting cell proliferation and inhibiting apoptosis and that the novel miR-24-3p/TRIM11 axis may be a useful new target for treating patients with CC.
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