期刊
ONCOTARGET
卷 7, 期 37, 页码 60736-60751出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.11177
关键词
exosomes; solid tumor; metastasis; immunoregulation; clinical applications
资金
- National Natural Science Foundation of China [81472666]
- Key Projects in the National Science & Technology Pillar Program during the Twelfth Five-year Plan Period [2014BAI09B07]
- Fundamental Research Funds for the Central Universities [2016FZA7011]
Exosomes are extracellular vesicles with diameters ranging from 30 to 150 nm. They can be secreted by all cell types and transfer information in the form of their contents, which include proteins, lipids and nucleic acids, to other cells throughout the body. They have roles in normal physiological processes as well as in disease development. Here, we review recent findings regarding tumor-derived exosomes, including methods for their extraction and preservation. We also describe the actions of exosomes in tumorigenesis. The exosomal antigen-presenting effect during antitumor immune responses and its suppressive function in immune tolerance are discussed. Finally, we describe the potential application of exosomes to cancer therapy and liquid biopsy.
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