期刊
CLINICAL ONCOLOGY
卷 27, 期 3, 页码 168-175出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.clon.2014.11.024
关键词
Head and neck carcinoma; hypoxic radiosensitisation; nimorazole; pharmacokinetics; toxicity
类别
资金
- Faculty of Health Sciences, Aarhus University
- CIRRO - The Lundbeck Foundation Centre for Interventional Research in Radiation Oncology
- Danish Council for Strategic Research [0603-00136B]
- DAHANCA - Danish Head and Neck Cancer Group
Aims: To study the pharmacokinetic characteristics of the hypoxic radiosensitiser nimorazole in patients with head and neck squamous cell carcinoma. Materials and methods: The pharmacokinetics of the hypoxic radiosensitiser nimorazole were studied in 63 patients treated in the DAHANCA-5 trial. After the first day of treatment, serial venous blood samples were taken and plasma concentrations of nimorazole measured by high pressure liquid chromatography (HPLC). Plasma concentration profiles were subjected to non-compartmental pharmacokinetic analysis using validated PC-b ased software. The different pharmacokinetic parameters were calculated and correlated with the different patient-and treatment-related variables. Results: HPLC measurements showed a linear relationship between peak plasma concentration and administered dose. The mean peak concentration adjusted for dose (in g/m(2)) was 32.2 +/- 0.9 mg/ml. The time of peak concentration ranged between 30 and 180 min (median 60 min). Plasma elimination occurred with a mean half-life of 3.35 +/- 0.09 h and was not significantly altered as a function of dose. There was a well-established linearelinear relationship between area under the concentrationetime curve (AUC; mean 191 +/- 6 mu g center dot h/ml) and administered dose, especially when expressed as g/m(2). The mean apparent volume of distribution was 0.77 +/- 0.02 l/kg. A statistically significant longer elimination half-life in men relative to women (mean difference 0.40 h; 95% confidence interval 0.77-0.03; P 0.03) was detected. Nimorazole was well tolerated; with 67% of patients reporting no toxicity; nausea/vomiting was the most reported toxicity in the remaining patients. Conclusion: The study supports the current nimorazole dose scheduling in patients. (C) 2014 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.
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