期刊
ONCOTARGET
卷 7, 期 32, 页码 52017-52031出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.10470
关键词
tumor; metabolic rewiring; PET-imaging; metabolomics-mass-spectrometry; oncogenic-K-ras
资金
- SysBioNet project, a MIUR initiative for the Italian Roadmap of European Strategy Forum on Research Infrastructures (ESFRI)
Oncogenic K-ras is capable to control tumor growth and progression by rewiring cancer metabolism. In vitro NIH-Ras cells convert glucose to lactate and use glutamine to sustain anabolic processes, but their in vivo environmental adaptation and multiple metabolic pathways activation ability is poorly understood. Here, we show that NIH-Ras cancer cells and tumors are able to coordinate nutrient utilization to support aggressive cell proliferation and survival. Using PET imaging and metabolomics-mass spectrometry, we identified the activation of multiple metabolic pathways such as: glycolysis, autophagy recycling mechanism, glutamine and serine/glycine metabolism, both under physiological and under stress conditions. Finally, differential responses between in vitro and in vivo systems emphasize the advantageous and uncontrolled nature of the in vivo environment, which has a pivotal role in controlling the responses to therapy.
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