期刊
ONCOTARGET
卷 7, 期 24, 页码 37390-37406出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.8940
关键词
meta-analysis; ovarian epithelial carcinoma; dietary fat
资金
- Science and Technology Research Project Foundation of Shandong Province [2012GSF11845]
- National Nature Science Foundation of China [81372530]
- Science and Technology Plan Project Foundation of Jinan City [201303047]
Observational studies assessing the association of dietary fat and risk of ovarian cancer yield discrepant results. Pertinent prospective cohort studies were identified by a PubMed search from inception to December 2015. Sixteen independent case-control and nine cohort studies on dietary fat intake were included, with approximately 900,000 subjects in total. Relative risks (RRs) with 95% confidence intervals were pooled using a random effects model. Heterogeneity, sensitivity analysis and publication bias were assessed; subgroup analysis and analysis stratified by EOC histology were conducted. The reported studies showed a significant increase of ovarian cancer risk with high consumption of total-, saturated-, and trans-fats, while serous ovarian cancer was more susceptible to dietary fat consumption than other pathological subtypes. No evidence of positive association between dietary fat intake and ovarian cancer risk was provided by cohort studies. Menopausal status, hormone replacement therapy, body mass index (BMI), and pregnancy times, modified the objective associations. In conclusion, the meta-analysis findings indicate that high consumption of total, saturated and trans-fats increase ovarian cancer risk, and different histological subtypes have different susceptibility to dietary fat.
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