期刊
ONCOTARGET
卷 7, 期 28, 页码 44848-44856出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.8602
关键词
USP22; deubiquitylation; cancer; oncogene; ataxia
资金
- National Institute of Health
- National Institute of Environmental Health Sciences (NIEHS) [ES015010]
- American Cancer Society [RSG-07-154]
Deubiquitylases remove ubiquitin moieties from different substrates to regulate protein activity and cell homeostasis. Since this posttranslational modification plays a role in several different cellular functions, its deregulation has been associated with different pathologies. Aberrant expression of the Ubiquitin-Specific Peptidase 22 (USP22) has been associated with poor cancer prognosis and neurological disorders. However, little is known about USP22 role in these pathologies or in normal physiology. This review summarizes the current knowledge about USP22 function from yeast to human and provides an overview of the possible mechanisms by which USP22 is emerging as a potential oncogene.
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