期刊
ONCOTARGET
卷 7, 期 22, 页码 33237-33245出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.8909
关键词
angiogenesis; inflammation; thalidomide; cancer; teratogenesis
资金
- Wellcome Trust-NIH [098252/Z/12/Z]
- Intramural Research Program, NCI, NIH
- Intramural Research Program, NIA, NIH
- Wellcome Trust [098252/Z/12/Z] Funding Source: Wellcome Trust
Thalidomide, a drug known for its teratogenic side-effects, is used successfully to treat a variety of clinical conditions including leprosy and multiple myeloma. Intense efforts are underway to synthesize and identify safer, clinically relevant analogs. Here, we conduct a preliminary in vivo screen of a library of new thalidomide analogs to determine which agents demonstrate activity, and describe a cohort of compounds with anti-angiogenic properties, anti-inflammatory properties and some compounds which exhibited both. The combination of the in vivo zebrafish and chicken embryo model systems allows for the accelerated discovery of new, potential therapies for cancerous and inflammatory conditions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据