期刊
ONCOTARGET
卷 7, 期 17, 页码 23658-23667出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.8151
关键词
toll-like receptor 1; toll-like receptor 2; toll-like receptor 4; toll-like receptor 6; esophageal adenocarcinoma
资金
- Orion Research Foundation
- Thelma Makikyro Foundation
- Paivikki and Sakari Sohlberg Foundation
- Emil Aaltonen Foundation
- Georg C. and Mary Ehrnroot Foundation
- Finnish Medical Foundation
Background: Toll-like receptors (TLRs) recognize microbial and endogenous ligands and have already shown to play a role in esophageal cancer. In this study, we evaluated especially TLRs that sense bacterial cell wall components in Barrett's esophagus, dysplasia and esophageal adenocarcinoma. Methods: TLRs 1, 2, 4 and 6 were stained immunohistochemically and assessed in esophageal specimens from patients with esophageal dysplasia (n = 30) or adenocarcinoma (n = 99). Structures and lesions were evaluated including normal esophagus (n = 88), gastric (n = 67) or intestinal metaplasia (n = 51) without dysplasia, and low-grade (n= 42) or high-grade dysplasia (n = 37), and esophageal adenocarcinoma (n = 99). Results: We found TLR1, TLR2, TLR4 and TLR6 expression in all lesions. TLR expression increased in Barrett's mucosa and dysplasia. There was profound increase of TLR expression from gastric-to intestinal-type columnar epithelium. In cancers, high nuclear and cytoplasmic staining of TLR4 associated with metastatic disease and poor prognosis. Conclusions: TLR1, TLR2, TLR4 and TLR6 are upregulated during malignant changes of esophageal columnar epithelium. Increased TLR4 expression associates with advanced stage and poor prognosis in esophageal adenocarcinoma.
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