期刊
ONCOTARGET
卷 7, 期 13, 页码 15444-15459出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.6999
关键词
vascular disrupting agents; resistance; imaging; solutions
资金
- National Natural Science Foundation of China (NSFC) [30670603]
- Health and Family Planning Commission of the Zhejiang Province of China [2014PYA009]
The emergence of vascular disrupting agents (VDAs) is a significant advance in the treatment of solid tumors. VDAs induce rapid and selective shutdown of tumor blood flow resulting in massive necrosis. However, a viable marginal tumor rim always remains after VDA treatment and is a major cause of recurrence. In this review, we discuss the mechanisms involved in the resistance of solid tumors to VDAs. Hypoxia, tumor-associated macrophages, and bone marrow-derived circulating endothelial progenitor cells all may contribute to resistance. Resistance can be monitored using magnetic resonance imaging markers. The various solutions proposed to manage tumor resistance to VDAs emphasize combining these agents with other approaches including antiangiogenic agents, chemotherapy, radiotherapy, radioimmunotherapy, and sequential dual-targeting internal radiotherapy.
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