期刊
ONCOTARGET
卷 7, 期 13, 页码 16542-16566出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.7665
关键词
yeast; cellular aging; longevity; plant extracts; aging-delaying chemical compounds
资金
- Natural Sciences and Engineering Research Council (NSERC) of Canada
- Concordia University Chair Fund
- Concordia Undergraduate Research Award
- Fonds quebecois de la recherche sur la nature et les technologies Master's Research Scholarship Award
- Concordia University Graduate Fellowship Award
We discovered six plant extracts that increase yeast chronological lifespan to a significantly greater extent than any of the presently known longevity-extending chemical compounds. One of these extracts is the most potent longevity-extending pharmacological intervention yet described. We show that each of the six plant extracts is a geroprotector which delays the onset and decreases the rate of yeast chronological aging by eliciting a hormetic stress response. We also show that each of these extracts has different effects on cellular processes that define longevity in organisms across phyla. These effects include the following: 1) increased mitochondrial respiration and membrane potential; 2) augmented or reduced concentrations of reactive oxygen species; 3) decreased oxidative damage to cellular proteins, membrane lipids, and mitochondrial and nuclear genomes; 4) enhanced cell resistance to oxidative and thermal stresses; and 5) accelerated degradation of neutral lipids deposited in lipid droplets. Our findings provide new insights into mechanisms through which chemicals extracted from certain plants can slow biological aging.
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