期刊
ONCOTARGET
卷 7, 期 38, 页码 61215-61228出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.11304
关键词
long non-coding RNAs (IncRNAs); early embryo; WGCNA; single-cell RNA-seq; human embryogenesis
资金
- National Basic Research Project of China [2014CB964701, 2014CB964703]
- National Natural Science Foundation of China [81471485]
Epigenetics regulations have an important role in fertilization and proper embryonic development, and several human diseases are associated with epigenetic modification disorders, such as Rett syndrome, Beckwith-Wiedemann syndrome and Angelman syndrome. However, the dynamics and functions of long non-coding RNAs (IncRNAs), one type of epigenetic regulators, in human pre-implantation development have not yet been demonstrated. In this study, a comprehensive analysis of human and mouse early-stage embryonic IncRNAs was performed based on public single-cell RNA sequencing data. Expression profile analysis revealed that IncRNAs are expressed in a developmental stage specific manner during human early-stage embryonic development, whereas a more temporal-specific expression pattern was identified in mouse embryos. Weighted gene co-expression network analysis suggested that IncRNAs involved in human early-stage embryonic development are associated with several important functions and processes, such as oocyte maturation, zygotic genome activation and mitochondrial functions. We also found that the network of IncRNAs involved in zygotic genome activation was highly preservative between human and mouse embryos, whereas in other stages no strong correlation between human and mouse embryo was observed. This study provides insight into the molecular mechanism underlying IncRNA involvement in human pre-implantation embryonic development.
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