期刊
ONCOTARGET
卷 7, 期 34, 页码 54463-54473出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.9810
关键词
GalNAc-T6; glycosylation; lung adenocarcinoma; prognosis; overall survival
资金
- Ministry of Education, Culture, Sports, Science and Technology, Tokyo, Japan [24790394]
- Fukuoka Foundation for Sound Health Cancer Research Fund, Fukuoka, Japan
- National Natural Science Foundation of China [81302023, 81201801]
- Education Department of Liaoning Province [L2012278]
Background: Polypeptide N-acetylgalactosaminyltransferases (GalNAc-Ts) are important glycosyltransferases in cancer, but the clinical role of its individual isoforms is unclear. We investigated the clinical significance and survival relevance of one isoform, GalNAc-T6 in lung adenocarcinoma after curative resection. Results: GalNAc-T6 was identified in 27.8% (55/198) of patients, and statistically indicated advanced TNM stage (P = 0.069). Multivariate analysis showed GalNAc-T6 to be an independent predictor for reduced overall survival of patients (P = 0.027), and the result was confirmed with bootstraping techniques, and on line Kaplan-Meier Plotter and SurvExpress database analysis, respectively. Moreover, ROC curve demonstrated that GalNAc-T6 expression significantly improved the accuracy of survival prediction. Methods: With 198 paraffin-embedded tumor samples from lung adenocarcinoma patients, GalNAc-T6 expression was immunohistochemically assessed for the association with clinicopathological parameters. The prognostic significance was evaluated by Cox proportional hazards regression analysis with 1000 bootstraping. Kaplan-Meier Plotter, SurvExpress database analysis, and receiver-operating characteristic (ROC) curve were performed to provide further validation. Conclusions: GalNAc-T6 expression correlated significantly with advanced TNM stage, and independently predicted worse OS for lung adenocarcinoma.
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