期刊
ONCOTARGET
卷 7, 期 19, 页码 27350-27362出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.8439
关键词
period2; glioma; TP53; X-ray; U343 cells
资金
- Incubation Base of the National Key Laboratory for Cerebrocranial Diseases, Ningxia Medical University
- Department of Pathology of Ningxia Medical University Hospital
- Department of Radiotherapy of Ningxia Medical University Hospital
- National Natural Science Foundation of China [81160313]
The Period2 (Per2) gene is an essential component of the mammalian circadian clock and is strongly linked to glioma occurrence and its response to radiotherapy. Here, we examined the role of Per2 in the response to X-ray-induced DNA damage in U343 glioma cells and in a mouse cancer model. Following low dose X-ray irradiation, we observed that lowering Per2 expression using RNAi reduces DNA damage and cell death in U343 cells and glioma tissue. Additionally, Per2 was associated with increased TP53 activity and was involved in the DNA damage during TP53-mediated apoptosis. These findings suggest that Per2, a core circadian gene, is not only a tumor suppressor gene but can also be regarded as an upstream regulator of TP53. It thus appears that Per2 is an important inhibitor of tumor growth that acts by increasing TP53 expression, DNA damage repair, and apoptosis.
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