期刊
ONCOTARGET
卷 7, 期 52, 页码 87114-87123出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.13513
关键词
gastric cancer; TINCR; polymorphism; genotype
资金
- Medical ZhongDianRenCai Project of Jiangsu Province [RC2011059]
- Natural Science Foundation of Jiangsu Province [BK20131447 (DA13)]
- Six RenCai Gaofeng
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) [JX10231801]
Tissue differentiation-inducing non-protein coding RNA (TINCR) is required for normal epidermal differentiation. TINCR is also strongly overexpressed in human gastric cancer (GC) and contributes to carcinogenesis and tumor progression. However, the association between TINCR polymorphisms and the risk of any diseases, such as GC, remains unknown. In the present study, the tag single nucleotide polymorphisms rs8113645, rs2288947, rs8105637, and rs12610531 were analyzed in 602 patients with GC and 602 age-and sex-matched controls. Polymorphisms were genotyped using TaqMan technology. Carriers of variant rs8113645 and rs2288947 alleles indicated reduced risks of GC (p = 0.003 and 0.037, respectively). A allele genotypes of rs8113645 and G allele genotypes of rs2288947 (rs8113645 GA and AA; rs2288947 AG and GG) were also significantly associated with decreased GC risk (p < 0.05). Stratification analysis displayed that the correlations between GC risk and variant genotypes of both rs8113645 and rs2288947were more evident in younger individuals, men, nonsmokers, and individuals from rural areas. We also demonstrated that rs8113645 GA+AA genotype carriers had lower TINCR mRNA expression levels compared with common genotype in both normal and GC tissues (p < 0.05). These results suggest that long non-coding RNA TINCR polymorphisms may be implicated in GC development.
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