期刊
ONCOTARGET
卷 7, 期 30, 页码 48423-48431出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.10301
关键词
glioma; miR-200b; LDHA; proliferation; metabolism
资金
- Youth Project of Guangzhou Medical University [2013A38]
- Scientific Research Project of Guangzhou Municipal University [1201430219]
Lactate dehydrogenase A (LDHA) is involved in various cancers. In this study, we investigated the expression and function of LDHA in glioma. We found that LDHA was up-regulated in glioma samples. Furthermore, we found that overexpression of LDHA promoted proliferation, invasion and glycolysis in glioma cells. Luciferase reporter assays confirmed that LDHA was a direct target of miR-200b. miR-200b was found to be down-regulated in glioma samples, which was inversely correlated with LDHA expression. Repression of LDHA by miR-200b suppressed the glycolysis, cell proliferation and invasion of glioma cells. These results provide evidence that miR-200b acts as a tumor suppressor in glioma through the inhibition of LDHA both in vitro and in vivo. Targeting LDHA through miR-200b could be a potential therapeutic strategy in glioma.
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