4.3 Article

Disruption of the EZH2/miRNA/β-catenin signaling suppresses aerobic glycolysis in glioma

期刊

ONCOTARGET
卷 7, 期 31, 页码 49450-49458

出版社

IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.10370

关键词

EZH2; miRNA; beta-catenin; aerobic glycolysis; glioma

资金

  1. Research Special Fund For Public Welfare Industry of Health [201402008]
  2. National High Technology Research and Development Program of China (863) [2012AA02A508]
  3. National Natural Science Foundation of China [81472362, 81372709, 81302185]
  4. Jiangsu Province's Natural Science Foundation [BK20131019, BK20151585]
  5. Program for Advanced Talents within Six Industries of Jiangsu Province [2015-WSN-036]
  6. Jiangsu Province's Key Provincial Talents Program [RC2011051]
  7. Jiangsu Province's Key Discipline of Medicine [XK201117]
  8. Program for Development of Innovative Research Team in the First Affiliated Hospital of NJMU
  9. Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)

向作者/读者索取更多资源

EZH2 is up-regulated in various cancer types, implicating its role in tumorigenesis. Our recent data have shown that repression of EZH2 inhibited glioma growth by inhibition beta-catenin signaling. Here, we identified several miRNAs that were repressed by EZH2, which in turn regulate beta-catenin expression by its 3'UTR, such as miR-1224-3p, miR-328 and miR-214. Further, EZH2 silenced miR-328 expression by binding to miR-328 promoter and promoting methylation of miR-328 promoter. Finally, miR-328 largely abrogated EZH2 effects on beta-catenin expression and glucose metabolism in glioma cells. Taken together, we propose a model for a coordinated EZH2-beta-catenin oncoprotein axis, and epigenetic link between histone modification and DNA methylation, mediated by EZH2-scilenced miRNAs.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.3
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据