期刊
ONCOTARGET
卷 7, 期 31, 页码 50666-50681出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.9308
关键词
long noncoding RNAs; hematopoiesis; hematological malignancies; transcriptional regulation; translation regulation
资金
- AIRC [10136, 16722]
- AIRC Special Program Molecular Clinical Oncology [9980]
- Ministero Italiano dell'Istruzione, Universita e Ricerca (MIUR) [2009PKMYA2]
Long non coding RNAs (lncRNAs) are defined as ncRNAs of more than 200 nt in length. They are involved in a large spectrum of biological processes, such as maintenance of genome integrity, genomic imprinting, cell differentiation, and development by means of mechanisms that remain to be fully elucidated. Besides their role in normal cellular physiology, accumulating evidence has linked lncRNA expression and functions to cancer development and progression. In this review, we summarize and discuss what is known about their expression and roles in hematopoiesis with a particular focus on their cell-type specificity, functional interactions, and involvement in the pathobiology of hematological malignancies.
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