4.3 Article

ZYG11A serves as an oncogene in non-small cell lung cancer and influences CCNE1 expression

期刊

ONCOTARGET
卷 7, 期 7, 页码 8029-8042

出版社

IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.6904

关键词

ZYG11A; CCNE1; NSCLC; Bioinformatics; Oncogene

资金

  1. Natural Science Foundation of China [81372321, 81472200, 81472702]
  2. Jiangsu Provincial Special Program of Medical Science Funding [BL2012030]
  3. National Science Foundation for Young Scholars [81302013]
  4. Jiangsu Provincial Six talent peak of Human affair Hall Funding [WSN-037]

向作者/读者索取更多资源

By analyzing The Cancer Genome Atlas (TCGA) database, we identified ZYG11A as a potential oncogene. We determined the expression of ZYG11A in NSCLC tissues and explored its clinical significance. And also evaluated the effects of ZYG11A on NSCLC cell proliferation, migration, and invasion both in vitro and in vivo. Our results show that ZYG11A is hyper-expressed in NSCLC tissues compared to adjacent normal tissues, and increased expression of ZYG11A is associated with a poor prognosis (HR: 2.489, 95% CI: 1.248-4.963, p = 0.010). ZYG11A knockdown induces cell cycle arrest and inhibits proliferation, migration, and invasion of NSCLC cells. ZYG11A knockdown also results in decreased expression of CCNE1. Over-expression of CCNE1 in cells with ZYG11A knockdown restores their oncogenic activities. Our data suggest that ZYG11A may serve as a novel oncogene promoting tumorigenicity of NSCLC cells by inducing cell cycle alterations and increasing CCNE1 expression.

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