期刊
ONCOTARGET
卷 7, 期 36, 页码 58671-58683出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.10945
关键词
decellularized scaffold; extracellular matrix; regeneration; organ; in vivo/in vitro
资金
- Natural Science Foundation of Zhejiang Province [LY12H15002, LY14H050005, LY14H180008, LY13H030010]
- Science Technology Department of Zhejiang Province [2014C37005]
- National Natural Science Foundation of China [81071576]
Allogeneic organ transplantation remains the ultimate solution for end-stage organ failure. Yet, the clinical application is limited by the shortage of donor organs and the need for lifelong immunosuppression, highlighting the importance of developing effective therapeutic strategies. In the field of regenerative medicine, various regenerative technologies have lately been developed using various biomaterials to address these limitations. Decellularized scaffolds, derived mainly from various non-autologous organs, have been proved a regenerative capability in vivo and in vitro and become an emerging treatment approach. However, this regenerative capability varies between scaffolds as a result of the diversity of anatomical structure and cellular composition of organs used for decellularization. Herein, recent advances in scaffolds based on organ regeneration in vivo and in vitro are highlighted along with aspects where further investigations and analyses are needed.
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