期刊
ONCOTARGET
卷 7, 期 32, 页码 51773-51783出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.10575
关键词
bladder cancer; microRNA-877-3p; p16; RNA activation
资金
- Public Welfare Technology Application Research project of Zhejiang Provincial Science, Technology Department of China [2014C33198]
- Zhejiang Provincial Natural Science Foundation of China [LY16H160015]
- National Natural Science Foundation of China [81372773, 81472375, 81402096, 8150100928]
- scientific research foundation of the ministry of public health [WKJ2012-2-009]
- Zhejiang province key project of science and technology [2014C04008-2]
Despite the recent studies which have shown that microRNA (miRNA) negatively regulates gene expression by silencing the expression of target genes, here we reported the new evidence of microRNA-mediated gene activation by targeting specific promoter sites. We identified a miR-877-3p binding site on the promoter site of tumor suppressor gene p16 which alters frequently in bladder cancer. Enforced expression of miR-877-3p could increase the expression of p16, which inhibit the proliferation and tumorigenicity of bladder cancer through cell cycle G1-phase arrest. Further evidences confirmed that the correlation between p16 activation and miR-877-3p was due to the direct binding. These findings demonstrate the anti-tumor function of miR-877-3p in bladder cancer cells and reveal a new pattern of miRNA involved gene regulation.
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