期刊
ONCOTARGET
卷 8, 期 8, 页码 14147-14157出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.13122
关键词
MUC4; carcinoma; epithelial; tumorigenicity
资金
- Chinese National Science Foundation [30571374, 30771603, 31072136, 31270171, 31672579]
- State Key Laboratory of Veterinary Biotechnology Foundation [SKLVBF2017]
- Genetically Modified Organisms Technology Major Project of China [2014ZX08006-001B]
- 948 program grant from the Ministry of Agriculture of the People's Republic of China [2011-G24]
- Yangzhou University
The cell surface membrane-bound mucin protein MUC4 promotes tumorigenicity, aggressive behavior, and poor outcomes in various types of epithelial carcinomas, including pancreatic, breast, colon, ovarian, and prostate cancer. This review summarizes the theories and findings regarding MUC4 function, and its role in epithelial carcinogenesis. Based on these insights, we developed an outline of the processes and mechanisms by which MUC4 critically supports the propagation and survival of cancer cells in various epithelial organs. MUC4 may therefore be a useful prognostic and diagnostic tool that improves our ability to eradicate various forms of cancer.
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