期刊
ONCOTARGET
卷 7, 期 27, 页码 41748-41757出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.9410
关键词
MAP4K3; GCK-like kinase (GLK); cancer recurrence; NSCLC; lung cancer
资金
- National Health Research Institutes, Taiwan [98A1-IMPP01-014]
- Taichung Veterans General Hospital, Taiwan [TCVGH-100NHRI03]
Lung cancer is the leading cause of cancer death worldwide. Non-small cell lung cancer (NSCLC) accounts for 85% of total lung cancers; 40% to 60% of NSCLC patients die of cancer recurrence after cancer resection. Since GLK (also named MAP4K3) induces activation of NF-.B, which contributes to tumor progression, we investigated the role of GLK in NSCLC. GLK protein levels of 190 samples from pulmonary tissue arrays and 58 pulmonary resection samples from stage I to stage III NSCLC patients were studied using immunohistochemistry or immunoblotting. High levels of GLK proteins were detected in pulmonary tissues from NSCLC patients. Elevated GLK protein levels were correlated with increased recurrence risks and poor recurrence-free survival rates in NSCLC patients after adjusting for pathologic stage, smoking status, alcohol status, and EGFR levels. Thus, GLK is a novel prognostic biomarker for NSCLC recurrence.
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