期刊
NUTRIENTS
卷 8, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/nu8060347
关键词
bone; dyslipidaemia; hyperglycaemia; hypertension; obesity; osteoporosis
资金
- Universiti Kebangsaan Malaysia [DIP-2014-040]
Metabolic syndrome (MetS) and osteoporosis are two major healthcare problems worldwide. Metabolic syndrome is a constellation of medical conditions consisting of central obesity, hyperglycemia, hypertension, and dyslipidemia, in which each acts on bone tissue in different ways. The growing prevalence of MetS and osteoporosis in the population along with the controversial findings on the relationship between both conditions suggest the importance for further investigation and discussion on this topic. This review aims to assess the available evidence on the effects of each component of MetS on bone metabolism from the conventional to the contemporary. Previous studies suggested that the two conditions shared some common underlying pathways, which include regulation of calcium homeostasis, receptor activator of NF-kappa B ligand (RANKL)/receptor activator of the NF-kappa B (RANK)/osteoprotegerin (OPG) and Wnt-beta-catenin signaling pathways. In conclusion, we suggest that MetS may have a potential role in developing osteoporosis and more studies are necessary to further prove this hypothesis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据