期刊
NUCLEIC ACID THERAPEUTICS
卷 26, 期 5, 页码 327-334出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/nat.2015.0591
关键词
microRNA; cancer; noncoding RNA; oligonucleotides; antagomirs
资金
- Council of Scientific and Industrial Research (CSIR), India [BSC0123]
miRNAs are highly conserved class of small ncRNAs whose involvement in human pathophysiologies is extensively investigated. MiR-21 is a well established oncogenic miRNA whose deregulation plays a significant role in onset and progression of cancer. The need of novel approaches to downregulate miR-21 is rapidly expanding. Potent inhibition of miR-21 is achieved by chemically modified 2-O-methyl RNA oligonucleotide. The serinol capping at 3 and 5ends and the interspersed 2-O-(R-2-amino-3-methoxypropyl) uridine units enhance the nuclease resistance and efficacy of 2-O-methyl RNA for the inhibition of miR-21. This represents a simple and novel modification for developing oligonucleotide-based therapeutics.
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