期刊
NEUROSCIENCE BULLETIN
卷 33, 期 1, 页码 62-72出版社
SPRINGER
DOI: 10.1007/s12264-016-0089-7
关键词
Parkinson's disease; Circadian rhythm; Sleep; Dopamine
资金
- National Natural Science Foundation of China [81471299]
- Jiangsu Provincial Special Program of Medical Science [BL2014042]
- Suzhou Clinical Key Disease Diagnosis and Treatment Technology Foundation [LCZX201304]
- Plans for Graduate Research and Innovation in Colleges and Universities of Jiangsu Province, China [KYZZ15_0334]
- Suzhou Medical Key Discipline Project
- Priority Academic Program Development of Jiangsu Higher Education Institutions, China (PAPD)
- Suzhou Clinical Research Center of Neurological Disease [Szzx201503]
Circadian rhythm is manifested by the behavioral and physiological changes from day to night, which is controlled by the pacemaker and its regulator. The former is located at the suprachiasmatic nuclei (SCN) in the anterior hypothalamus, while the latter is composed of clock genes present in all tissues. Circadian desynchronization influences normal patterns of day-night rhythms such as sleep and alertness cycles, rest and activity cycles. Parkinson's disease (PD) exhibits diurnal fluctuations. Circadian dysfunction has been observed in PD patients and animal models, which may result in negative consequences to the homeostasis and even exacerbate the disease progression. Therefore, circadian therapies, including light stimulation, physical activity, dietary and social schedules, may be helpful for PD patients. However, the cellular and molecular mechanisms that underlie the circadian dysfunction in PD remain elusive. Further research on circadian patterns is needed. This article summarizes the existing research on the circadian rhythms in PD, focusing on the clinical symptom variations, molecular changes, as well as the available treatment options.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据