期刊
NEUROSCIENCE BULLETIN
卷 32, 期 5, 页码 469-480出版社
SPRINGER
DOI: 10.1007/s12264-016-0055-4
关键词
Alzheimer's disease; Neuroinflammation; Cytokine; Genetic polymorphism
资金
- National Natural Science Foundation of China [91332104, 81201080]
- Program for New Century Excellent Talents in University, China [NCET-13-0117]
- Key Program for Clinical Medicine and Science and Technology of Jiangsu Province Clinical Medical Research Center, China [BL2013025]
- Natural Science Foundation of Jiangsu Province, China [BK2012337]
- National High-Tech R&D Program (863 Program) of China [SQ2015AA0200064]
- Ministry of Education of China [20120092120068]
- Graduate Candidate Research Innovation Program of Jiangsu Province, China [KYLX15_0188]
Neuroinflammatory processes are a central feature of Alzheimer's disease (AD) in which microglia are over-activated, resulting in the increased production of pro-inflammatory cytokines. Moreover, deficiencies in the anti-inflammatory system may also contribute to neuroinflammation. Recently, advanced methods for the analysis of genetic polymorphisms have further supported the relationship between neuroinflammatory factors and AD risk because a series of polymorphisms in inflammation-related genes have been shown to be associated with AD. In this review, we summarize the polymorphisms of both pro- and anti-inflammatory cytokines related to AD, primarily interleukin-1 (IL-1), IL-6, tumor necrosis factor alpha, IL-4, IL-10, and transforming growth factor beta, as well as their functional activity in AD pathology. Exploration of the relationship between inflammatory cytokine polymorphisms and AD risk may facilitate our understanding of AD pathogenesis and contribute to improved treatment strategies.
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