期刊
NATURE STRUCTURAL & MOLECULAR BIOLOGY
卷 23, 期 6, 页码 475-480出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.3231
关键词
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资金
- National Institutes of Health [R01GM097207, R01GM0997522]
- Lilly Research Award Program
- National Science Foundation [CHE-1415910]
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [1415910] Funding Source: National Science Foundation
The computational design of alpha-helical membrane proteins is still in its infancy but has already made great progress. De novo design allows stable, specific and active minimal oligomeric systems to be obtained. Computational reengineering can improve the stability and function of naturally occurring membrane proteins. Currently, the major hurdle for the field is the experimental characterization of the designs. The emergence of new structural methods for membrane proteins will accelerate progress.
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